Identification of native Bacillus thuringiensis strain from South India having specific cytocidal activity against cancer cells

To identify the parasporin-producing, indigenous Bacillus thuringiensis strains that specifically targets human cancer cells in Madurai, Tamil Nadu, South India.Alkali-solubilized inclusion proteins from the 82 nonclonal indigenous isolates of B. thuringiensis were analysed for their cytotoxicity against two human cancer cell lines, U-937 (human histiocytic lymphoma) and HCT-15 [corrected] (adherent human colon cancer cells). Activated inclusion...