Quality control in tRNA charging

Faithful translation of the genetic code during protein synthesis is fundamental to the growth, development, and function of living organisms. Aminoacyl‐tRNA synthetases (AARSs), which define the genetic code by correctly pairing amino acids with their cognate tRNAs, are responsible for ‘quality control’ in the flow of information from a gene to a protein. When differences in binding energies of amino acids to an AARS are inadequate, editing is...