Granulocyte/macrophage colony-stimulating factor treatment of human chronic ulcers promotes angiogenesis associated withde novovascular endothelial growth factor transcription in the ulcer bed

Summary Background Granulocyte/macrophage colony-stimulating factor (GM-CSF), a cytokine with pleiotropic functions, has been successfully employed in the treatment of chronic skin ulcers. The biological effects underlying GM-CSF action in impaired wound healing have been only partly clarified. Objectives To investigate the effects of GM-CSF treatment of chronic venous ulcers on lesion vascularization and on the local synthesis of the angiogenic...