H2O2 induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin

Published on Aug 1, 1995in Neuroscience Letters2.173
· DOI :10.1016/0304-3940(95)11803-5
Ewa Sewerynek21
Estimated H-index: 21
(University of Texas Health Science Center at San Antonio),
Burkhard Poeggeler36
Estimated H-index: 36
(University of Texas Health Science Center at San Antonio)
+ 1 AuthorsRussel J. Reiter149
Estimated H-index: 149
(University of Texas Health Science Center at San Antonio)
Abstract Melatonin protection against H 2 O 2 -induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H 2 O 2 alone or in combination with melatonin. Brain MDA + 4-HDA increased after H202 (0.1–5 mM) with the effect being both concentration- and time-dependent. Melatonin (0.1–5 mM) protected against H 2 O 2 -induced lipid peroxidation of brain homogenates in a concentration-dependent manner.
  • References (15)
  • Citations (55)
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