Abnormal sensorimotor plasticity in migraine without aura patients

Summary Impaired paired associative stimulation (PAS)-induced long-term synaptic plasticity characterizes migraine without aura patients between attacks. We suggest that the malfunctioning in PAS-induced effects in migraine reflects low cortical preactivation, which prevents short-term and longer-term changes in cortical synaptic effectiveness. The period between migraine attacks is characterized by paradoxical responses to repetitive sensory...