Tri- and diorganotin(IV) complexes of biologically important orotic acid: Synthesis, spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities

Tri-and diorganotin(IV) orotates of general formula, RnSn(H2Or)m [n = 3/2, m = 1/2, R = Me, n-Bu, n-Oct and Ph; H2Or− = monoanion of orotic acid (H3Or)] (n-Bu2Sn(HOr) as an exception) have been synthesized. On the basis of various spectroscopic studies it is revealed that R3Sn(H2Or) and R2Sn(H2Or)2 exhibit distorted trigonal–bipyramidal and distorted octahedral geometry, respectively, and n-Bu2Sn(HOr) shows both five and six coordination...