Impaired Proteasome Function in Alzheimer's Disease

: Inhibition of proteasome activity is sufficient to induce neuron degeneration and death ; however, altered proteasome activity in a neurodegenerative disorder has not been demonstrated. In the present study, we analyzed proteasome activity in short‐postmortem‐interval autopsied brains from 16 Alzheimer's disease (AD) and nine age‐ and sex‐matched controls. A significant decrease in proteasome activity was observed in the hippocampus and...