Induction of Endothelial Cell Activation by a Triple Helical α2β1 Integrin Ligand, Derived from Type I Collagen α1(I)496–507

Endothelial cell activation involves the elevated expression of cell adhesion molecules, chemoattractants, chemokines, and cytokines. These expression profiles may be regulated by integrin-mediated cell signaling pathways. In the current study, an α2β1 integrin triple helical peptide ligand derived from type I collagen residues α1(I)496–507 was examined for induction of human aortic endothelial cell (HAEC) activation. In addition, a...