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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Published on Apr 1, 2001in Diabetes Care 13.40
· DOI :10.2337/diacare.24.4.683
Bo Isomaa46
Estimated H-index: 46
,
Peter Almgren63
Estimated H-index: 63
+ 5 AuthorsLeif Groop128
Estimated H-index: 128
Abstract
OBJECTIVE —To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WHO). RESEARCH DESIGN AND METHODS —A total of 4,483 subjects aged 35–70 years participating in a large family study of type 2 diabetes in Finland and Sweden (the Botnia study) were included in the analysis of cardiovascular risk associated with the metabolic syndrome. In subjects who had type 2 diabetes ( n = 1,697), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) ( n = 798), or insulin-resistance with normal glucose tolerance (NGT) ( n = 1,988), the metabolic syndrome was defined as presence of at least two of the following risk factors: obesity, hypertension, dyslipidemia, or microalbuminuria. Cardiovascular mortality was assessed in 3,606 subjects with a median follow-up of 6.9 years. RESULTS —In women and men, respectively, the metabolic syndrome was seen in 10 and 15% of subjects with NGT, 42 and 64% of those with IFG/IGT, and 78 and 84% of those with type 2 diabetes. The risk for coronary heart disease and stroke was increased threefold in subjects with the syndrome ( P P P = 0.002). CONCLUSIONS —The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from different studies.
  • References (34)
  • Citations (3813)
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References34
Newest
Published on Feb 8, 2000in Diabetologia 6.02
Seppo Lehto47
Estimated H-index: 47
,
Tapani Rönnemaa78
Estimated H-index: 78
+ 1 AuthorsMauri Laakso132
Estimated H-index: 132
Aims/hypothesis. Information on the association of hyperinsulinaemia with coronary heart disease (CHD) in patients with Type II (non-insulin-dependent) diabetes is limited and controversial. Therefore, we carried out a prospective study to examine the predictive value of fasting plasma insulin and “hyperinsulinaemia cluster” with regard to the risk of CHD mortality.¶Methods. At baseline risk factors for CHD were determined in 902 patients aged 45 to 64 years with Type II diabetes not treated by ...
160 Citations Source Cite
Knut Borch-Johnsen70
Estimated H-index: 70
,
Bo Feldt-Rasmussen31
Estimated H-index: 31
+ 2 AuthorsJan Skov Jensen49
Estimated H-index: 49
Abstract —Cross-sectional studies suggest that an increased urinary albumin excretion rate is associated with cardiovascular disease, dyslipidemia, and hypertension. The purpose of this study was to analyze prospectively whether the urinary albumin-to -creatinine (A/C) ratio can independently predict ischemic heart disease (IHD) in a population-based cohort. In 1983, urinary albumin and creatinine levels were measured, along with the conventional atherosclerotic risk factors, in 2085 consecutive...
423 Citations Source Cite
Published on Feb 1, 1999in Journal of Internal Medicine 6.75
Rantala Ao21
Estimated H-index: 21
(University of Oulu),
Heikki Kauma32
Estimated H-index: 32
(University of Oulu)
+ 3 AuthorsY. A. Kesäniemi30
Estimated H-index: 30
(University of Oulu)
Objectives. To determine the prevalence of the metabolic abnormalities associated with hypertension and to define the predictors of the metabolic syndrome by different definitions in random population-based samples. Design. A cross-sectional epidemiological study of hypertensive patients and controls. Setting. The participating study subjects visited the research laboratory of the Department of Internal Medicine, University of Oulu, Oulu, Finland. Subjects. Six hundred treated male and female hy...
184 Citations Source Cite
Published on Jan 1, 1999in Diabetes 7.27
Tiinamaija Tuomi74
Estimated H-index: 74
,
A. Carlsson7
Estimated H-index: 7
+ 12 AuthorsBörje Snickars2
Estimated H-index: 2
The aim of the study was 1) to establish the prevalence of GAD antibodies (GADab) in a population-based study of type 2 diabetes in western Finland, 2) to genetically and phenotypically characterize this subgroup, and 3) to provide a definition for latent autoimmune diabetes in adults (LADA). The prevalence of GADab was 9.3% among 1,122 type 2 diabetic patients, 3.6% among 558 impaired glucose tolerance (IGT) subjects, and 4.4% among 383 nondiabetic control subjects. Islet antigen 2 antibodies (...
391 Citations Source Cite
Published on Oct 1, 1998in Diabetes 7.27
E. Bonora17
Estimated H-index: 17
,
Stefan Kiechl75
Estimated H-index: 75
+ 6 AuthorsMichele Muggeo62
Estimated H-index: 62
The prevalence of insulin resistance in the most common metabolic disorders is still an undefined issue. We assessed the prevalence rates of insulin resistance in subjects with impaired glucose tolerance (IGT), NIDDM, dyslipidemia, hyperuricemia, and hypertension as identified within the frame of the Bruneck Study. The study comprised an age- and sex-stratified random sample of the general population (n = 888; aged 40-79 years). Insulin resistance was estimated by homeostasis model assessment (H...
664 Citations Source Cite
Published on Jul 1, 1998in Diabetic Medicine 3.13
K. G. M. M. Alberti53
Estimated H-index: 53
(Newcastle University),
Paul Zimmet108
Estimated H-index: 108
The classification of diabetes mellitus and the tests used for its diagnosis were brought into order by the National Diabetes Data Group of the USA and the second World Health Organization Expert Committee on Diabetes Mellitus in 1979 and 1980. Apart from minor modifications by WHO in 1985, little has been changed since that time. There is however considerable new knowledge regarding the aetiology of different forms of diabetes as well as more information on the predictive value of different blo...
10.3k Citations Source Cite
Published on May 1, 1998in Diabetes 7.27
Leena Mykkänen63
Estimated H-index: 63
,
Daniel J. Zaccaro23
Estimated H-index: 23
+ 3 AuthorsS. M. Haffner57
Estimated H-index: 57
Microalbuminuria is associated with excess cardiovascular mortality in both diabetic and nondiabetic subjects. Patients with NIDDM and microalbuminuria are more insulin resistant than those without microalbuminuria. However, the relationship between insulin resistance and microalbuminuria in patients with NIDDM could be due to hyperglycemia, which can cause both insulin resistance and an increase in albumin excretion rate. Little is known about microalbuminuria and insulin resistance in nondiabe...
302 Citations Source Cite
Published on Aug 1, 1997in Journal of Cardiovascular Risk
Mauno Vanhala32
Estimated H-index: 32
,
Esko Kumpusalo27
Estimated H-index: 27
+ 1 AuthorsJorma Takala17
Estimated H-index: 17
Objective To investigate methods for the detection of different clusterings of the insulin-resistant abnormalities consistent with the concept of the ‘metabolic syndrome’ in clinical practice, and to research the occurrence of these clusters in a middle-aged Finnish population.Methods We studied a random sample of 207 middle-aged subjects in the city of Tampere, and all 1148 subjects of four middle-aged age groups in Pieksamaki town, in central Finland. Clusterings of the following eight markers...
49 Citations Source Cite
Cited By3813
Newest
Published on Feb 7, 2019in Scientific Reports 4.12
Noushin Sadat Ahanchi (Shahid Beheshti University of Medical Sciences and Health Services), Farzad Hadaegh26
Estimated H-index: 26
(Shahid Beheshti University of Medical Sciences and Health Services)
+ 3 AuthorsDavood Khalili20
Estimated H-index: 20
(Shahid Beheshti University of Medical Sciences and Health Services)
In this study, using latent class analysis (LCA), we investigated whether there are any homogeneous subclasses of individuals exhibiting different profiles of metabolic syndrome (MetS) components. The current study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS), a population-based cohort including 6448 subjects, aged 20–50 years. We carried out a LCA on MetS components and assessed the association of some demographic and behavioral variables with membership of la...
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Published on Feb 4, 2019in Diabetology & Metabolic Syndrome 2.41
Makoto Shiraishi1
Estimated H-index: 1
(Kyoto Prefectural University of Medicine),
Muhei Tanaka18
Estimated H-index: 18
(Kyoto Prefectural University of Medicine)
+ 7 AuthorsMichiaki Fukui30
Estimated H-index: 30
(Kyoto Prefectural University of Medicine)
Background Metabolic syndrome is characterized by the clustering of different metabolic abnormalities. Total bilirubin and gamma-glutamyltransferase (GGT) levels have been reported to be associated with this condition. However, the extent to which the interaction between these parameters affects metabolic syndrome is unknown. Therefore, we examined the association of total bilirubin and GGT levels with metabolic syndrome, and investigated the combined effect of the two parameters.
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Published on Jan 23, 2019in BMC Cardiovascular Disorders 1.81
Shuangkun Chen (Fujian Medical University), Jiahui Li (Fujian Medical University)+ 3 AuthorsLiang-Wan Chen9
Estimated H-index: 9
(Fujian Medical University)
Background Metabolic syndrome (MetS) is a prevalent risk factor for coronary artery disease progression. Past studies have shown that MetS and its components tends to increase mortality after coronary artery bypass grafting (CABG), but data on the impact of MetS on postoperative outcome in patients with a left ventricular (LV) ejection fraction (EF) < 50% are still lacking.
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Published on Mar 18, 2019in Lipids in Health and Disease 2.66
Ferruccio Galletti23
Estimated H-index: 23
(University of Naples Federico II),
Valeria Fazio4
Estimated H-index: 4
(University of Naples Federico II)
+ 10 AuthorsN. Brambilla2
Estimated H-index: 2
Background Nutraceuticals represent a new therapeutic frontier in the treatment of metabolic syndrom (MetS) and related cardiovascular risk factors. The aim of this study was to evaluate the potential beneficial effects of Armolipid Plus (AP) (berberine 500 mg, red yest rice, monacolin K 3 mg and policosanol 10 mg) on insulin resistance, lipid profile, particularly on small and dense LDL cholesterol (sdLDL-C), representing the most atherogenic components, as well as its effects on high sensitivi...
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Published on Apr 1, 2019in Environmental Research 4.73
Nai-Yueh Ko1
Estimated H-index: 1
(National Defense Medical Center),
Yuan-Ting C. Lo2
Estimated H-index: 2
(National Defense Medical Center)
+ 3 AuthorsHan-Bin Huang5
Estimated H-index: 5
(National Defense Medical Center)
Abstract Background Information on the relationships between phthalate exposure, insulin resistance, and metabolic syndrome (MetS) in younger adults is limited. It is still unclear whether changes in insulin resistance represent an intermediate biological mechanism linking phthalate exposure and MetS. Objective To investigate the associations between cumulative risk of phthalates (such as daily intake [DI] and hazard index [HI]), insulin resistance, and MetS in younger adults and to examine the ...
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Published on Jul 4, 2019in Platelets 2.36
Matteo Nardin8
Estimated H-index: 8
(University of Brescia),
Monica Verdoia18
Estimated H-index: 18
+ 1 AuthorsGiuseppe De Luca42
Estimated H-index: 42
AbstractPlatelets represent one of the main actors involved in pathogenesis of coronary artery disease (CAD). Mean platelet volume (MPV) has been proposed as marker of platelet reactivity and thrombotic risk. However, still debated is whether higher MPV constitutes an independent determinant of CAD or just the consequence of an association with several cardiovascular risk factors. Therefore, the aim of the present study was to assess the impact of metabolic syndrome (MetS), on MPV and its relati...
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Published on Jun 3, 2019in International Journal of Neuroscience 1.85
Charles I. Mosimah (West Virginia University), Pamela J. Murray24
Estimated H-index: 24
(West Virginia University),
James W. Simpkins67
Estimated H-index: 67
(West Virginia University)
AbstractMetabolic syndrome is a cluster of cardiovascular risk factors associated with a prothrombotic, proinflammatory and hypofibrinolysis state. Although resistance to tissue plasminogen activator (tPA) in metabolic syndrome patients has been associated with a defective fibrinolytic system, the factors and mechanisms underlining such resistance is unclear. While there is a great debate on proposed mechanisms, fundamental questions regarding resistance to tPA in metabolic syndrome patients wit...
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Published on May 2, 2019in Cellulose 3.81
Ragnhild Aaen , Sébastien Simon18
Estimated H-index: 18
+ 1 AuthorsKristin Syverud22
Estimated H-index: 22
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Published on May 16, 2019in Expert Review of Clinical Immunology 3.44
Chi Chiu Mok3
Estimated H-index: 3
(Tuen Mun Hospital)
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