A Novel Pax5-Binding Regulatory Element in the Igκ Locus
Abstract
The Igκ locus undergoes a variety of different molecular processes during B cell development, including V(D)J rearrangement and somatic hypermutations, which are influenced by cis regulatory regions (RR) within the locus. The Igκ locus includes three characterized RRs termed the intronic (iEκ), 3’Eκ and Ed enhancers. We had previously noted that a region of DNA upstream of the iEκ and matrix attachment region (MAR) was necessary for...
Paper Details
Title
A Novel Pax5-Binding Regulatory Element in the Igκ Locus
Published Date
May 23, 2014
Journal
Volume
5
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