PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

It is currently thought that the effects of PPARγ activation on glucose homeostasis may be due to the effect of this nuclear receptor on the production of adipocyte-derived signalling molecules, which affect muscle glucose metabolism. Potential signalling molecules derived from adipocytes and modified by PPARγ activation include TNFα and leptin, which both interfere with glucose homeostasis. In addition to its effects on these proteins, PPARγ...