Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

By acting as a mild mitochondrial uncoupler, a derivative of the approved drug niclosamide may offer a new approach to treat diabetes. Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective in correcting its underlying cause. One important causal factor of T2D is ectopic accumulation of lipids in metabolically sensitive organs such as liver...