Gene silencing of SLC5A8 identified by genome-wide methylation profiling in lung cancer

Background Aberrant DNA hypermethylation has been implicated as a component of an epigenetic mechanism that silences genes in cancers. Methods We performed a genome-wide search to identify differentially methylated loci between 26 tumor and adjacent non-tumor paired tissues from same lung cancer patients using restriction landmark genomic scanning (RLGS) analysis. Among 229 loci which were hypermethylated in lung tumors as compared to adjacent...