Variable protection of β3-integrin–deficient mice from thrombosis initiated by different mechanisms
Abstract
Platelet integrin αIIbβ3 (GPIIb/IIIa) plays a central role in the initiation of arterial thrombosis, but its contribution to disseminated microvascular thrombosis is less well defined. Therefore, wild-type mice (β3+/+), β3-integrin–deficient mice (β3−/−), and wild-type mice treated with a hamster monoclonal antibody (1B5) that blocks murine αIIbβ3 function were tested in models of large-vessel and microvascular thrombosis. In the large-vessel...
Paper Details
Title
Variable protection of β3-integrin–deficient mice from thrombosis initiated by different mechanisms
Published Date
Aug 15, 2001
Journal
Volume
98
Issue
4
Pages
1055 - 1062
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