Asynchronous Replication, Mono-Allelic Expression, and Long Range Cis-Effects of ASAR6
Abstract
Mammalian chromosomes initiate DNA replication at multiple sites along their length during each S phase following a temporal replication program. The majority of genes on homologous chromosomes replicate synchronously. However, mono-allelically expressed genes such as imprinted genes, allelically excluded genes, and genes on female X chromosomes replicate asynchronously. We have identified a cis-acting locus on human chromosome 6 that controls...
Paper Details
Title
Asynchronous Replication, Mono-Allelic Expression, and Long Range Cis-Effects of ASAR6
Published Date
Apr 4, 2013
Journal
Volume
9
Issue
4
Pages
e1003423 - e1003423
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