Substrate Deactivation of Phenylalanine-Sensitive 3-Deoxy-d -arabino-heptulosonate 7-Phosphate Synthase by Erythrose 4-Phosphate
Abstract
3-Deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS, EC 4.1.2.15) catalyzes the condensation of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to give DAH7P via an ordered sequential mechanism. In the absence of PEP (the first substrate to bind), E4P binds covalently to the phenylalanine-sensitive DAH7PS of Escherichia coli, DAH7PS(Phe), deactivating the enzyme. Activity is restored on addition of excess PEP but not if...
Paper Details
Title
Substrate Deactivation of Phenylalanine-Sensitive 3-Deoxy-d -arabino-heptulosonate 7-Phosphate Synthase by Erythrose 4-Phosphate
Published Date
Nov 15, 2001
Journal
Volume
40
Issue
49
Pages
14821 - 14828
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