Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

Volume: 44, Issue: 1, Pages: 40 - 46
Published: Jan 1, 2012
Abstract
Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes1. Genome-scale studies have yielded important insights into these changes2, 3, 4, 5 but have focused on CpG islands or gene promoters. We used whole-genome bisulfite sequencing (bisulfite-seq) to comprehensively profile a primary human colorectal tumor and adjacent normal colon tissue at...
Paper Details
Title
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Published Date
Jan 1, 2012
Volume
44
Issue
1
Pages
40 - 46
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