Synthesis of organoarsenic, organoantimony, and organobismuth poly(ether esters) from reaction with glycyrrhetinic acid and their preliminary activity against pancreatic cancer cell lines

Published on Jun 1, 2013in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2013.812281
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Ngoc Trang Caroline Truong2
Estimated H-index: 2
(Florida Atlantic University)
+ 2 AuthorsNancy T. Trang5
Estimated H-index: 5
(University of Texas at Arlington)
Abstract
Polyether esters were rapidly formed employing the interfacial condensation of Group VA triphenylmetal dihalides with glycyrrhetinic acid in moderate yield and chain length. Infrared spectroscopy shows the formation of metal–oxygen bonds. The products are a mixture of bridging and non-bridging structures about the metal atom. Proton NMR and MALDI MS results are consistent with the formation of the polyether esters. Some of the polymers exhibit inhibition of the growth of pancreatic cancer cell lines.
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  • Citations (8)
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References66
Published on Jan 1, 2004in Journal of Polymer Materials 0.35
Ce Carraher1
Estimated H-index: 1
,
K Morie1
Estimated H-index: 1
8 Citations
Published on May 20, 1976in Angewandte Makromolekulare Chemie
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Leonard M. Jambaya3
Estimated H-index: 3
(University of South Dakota)
Hafnium polyethers were synthesized utilizing both the interfacial and aqueous solution techniques: Thermal properteis of the polyethers were studied by DSC and TGA analysis. The products exhibit moderate to poor low and high temperature stabilities. Degradation above 200°C occurs via an oxidative mode in air. Hafniumhaltige Polyather wurden auf folgendem Weg durch Grenzflachenpolykondensation und durch Polykondensation in Losung dargestellt: Die thermischen Eigenschaften der Polyather wurden du...
14 Citations Source Cite
Published on Feb 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
Poly[alkylene(arylene)oxystannanes] of the form below have been synthesized from dichlorostannanes and diols using a modified nonaqueous interfacial system consisting of acetonitrile and hydrocarbons. The products are preferentially capped with alcohol end-groups. Poly[alkylen(arylen)oxystannane] der folgenden Struktur wurden durch Grenzflachenpolykondensation von Dichlorstannen mit Diolen hergestellt. Dabei wurden modifizierte wasserfreie Losungsmittelsysteme aus Acetonitril und Kohlenwassersto...
25 Citations Source Cite
Published on Oct 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
The synthesis of some poly(tin ethers) according to the following route is described The number average polymerization degrees range from 78 to 1400. Die Synthese einiger Poly-(zinnather) wird beschrieben, und zwar durch die in der Summary wiedergegebene Reaktion. Die mittleren Polymerisationsgrade liegen im Bereich von 78 bis 1400.
27 Citations Source Cite
Published on Oct 25, 1974in Angewandte Makromolekulare Chemie
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Leonard M. Jambaya3
Estimated H-index: 3
(University of South Dakota)
The synthesis via interfacial and aqueous solution techniques of zirconium polyethers has been accomplished: Polymer yield seeks a maximum around a molar ratio of Cp2ZrCl2: Diol: Base of 1:1:2. Zirkoniumhaltige Polyather wurden auf folgendem Weg durch Grenzflachenpolykondensation und Losungspolykondensation hergestellt: Das Maximum der Ausbeute wird bei einem Molverhaltnis Cp2ZrCl2: Diol : Base von 1 : 1 : 2 beobachtet.
7 Citations Source Cite
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Frank D. Blum25
Estimated H-index: 25
(Missouri University of Science and Technology)
+ 8 AuthorsMichael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
Polymers in general and metal-containing polymers in particular are often sparingly soluble or insoluble, in contrast to small molecules. Thus, special significance is attached to characterization techniques that can be applied to the materials as solids. Here, three techniques are discussed that give structural information gained from the solid material. Mossbauer spectroscopy is a powerful technique that may give information on the structure about the metal-containing moiety for about 44 diffe...
11 Citations Source Cite
Published on Sep 1, 2008in Planta Medica 2.49
Jin Yang8
Estimated H-index: 8
,
Liang Zhou1
Estimated H-index: 1
+ 2 AuthorsAndrew K. Davey20
Estimated H-index: 20
The major component of liquorice root extract, glycyrrhizinate (GZ), has been formulated as an injection for the treatment of hepatitis. If given orally, GZ has poor bioavailability and is catalysed to glycyrrhetinic acid (GA) by intestinal bacteria. GA is subsequently responsible for significant side effects. This study was conducted to clarify the relationship between GZ and GA absorption and bioavailability. GZ and GA absorption were investigated using the IN SITU single pass isolated perfuse...
5 Citations Source Cite
Published on May 1, 2012in Bioorganic & Medicinal Chemistry Letters 2.44
Lijun Wang16
Estimated H-index: 16
(Chinese Academy of Sciences),
Chang-An Geng14
Estimated H-index: 14
(Chinese Academy of Sciences)
+ 5 AuthorsJi-Jun Chen24
Estimated H-index: 24
(Chinese Academy of Sciences)
Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 mu M, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel ...
18 Citations Source Cite
Published on Jan 1, 2013in Antimicrobial Agents and Chemotherapy 4.26
Danyelle R. Long1
Estimated H-index: 1
(Montana State University),
Julia Mead1
Estimated H-index: 1
(Montana State University)
+ 2 AuthorsJovanka M. Voyich33
Estimated H-index: 33
(Montana State University)
Methicillin-resistant Staphylococcus aureus (MRSA) has become a major source of infection in hospitals and in the community. Increasing antibiotic resistance in S. aureus strains has created a need for alternative therapies to treat disease. A component of the licorice root Glycyrrhiza spp., 18β-glycyrrhetinic acid (GRA), has been shown to have antiviral, antitumor, and antibacterial activity. This investigation explores the in vitro and in vivo effects of GRA on MRSA pulsed-field gel electropho...
30 Citations Source Cite
Cited By8
Published on Nov 1, 2014in Inorganica Chimica Acta 2.26
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Ngoc Trang Caroline Truong2
Estimated H-index: 2
(Florida Atlantic University)
+ 3 AuthorsNancy T. Trang5
Estimated H-index: 5
(University of Texas at Arlington)
Abstract Polyether esters are rapidly formed employing the interfacial condensation of organotin dihalides with glycyrrhetinic acid in high yield and oligomeric to polymeric chain length. Infrared spectroscopy shows the formation of tin–oxygen bonds. The products are a mixture of bridging and non-bridging structures about the tin atom. Proton NMR and MALDI MS results are consistent with the formation of the poly(ether esters). The dimethyltin, dibutyltin, and diphenyltin polymers exhibit good in...
7 Citations Source Cite
Published on Sep 23, 2014in Molecules 3.10
Donal M. Keogan3
Estimated H-index: 3
,
Darren M. Griffith13
Estimated H-index: 13
(Royal College of Surgeons in Ireland)
: Bismuth compounds have been used extensively as medicines and in particular for the treatment of gastrointestinal ailments. In addition to bismuth’s well known gastroprotective effects and efficacy in treating H. pylori infection it also has broad anti-microbial, anti-leishmanial and anti-cancer properties. Aspects of the biological chemistry of bismuth are discussed and biomolecular targets associated with bismuth treatment are highlighted. This review strives to provide the reader with an up...
39 Citations Source Cite
Published on Jan 1, 2016in Chemical Society Reviews 40.18
Yi Yan11
Estimated H-index: 11
(Northwestern Polytechnical University),
Jiuyang Zhang18
Estimated H-index: 18
(Southeast University)
+ 1 AuthorsChuanbing Tang37
Estimated H-index: 37
(University of South Carolina)
A survey of the most recent progress in the biomedical applications of metal-containing polymers is given. Due to the unique optical, electrochemical, and magnetic properties, at least 30 different metal elements, most of them transition metals, are introduced into polymeric frameworks for interactions with biology-relevant substrates via various means. Inspired by the advance of metal-containing small molecular drugs and promoted by the great progress in polymer chemistry, metal-containing poly...
60 Citations Source Cite
Published on Jul 2, 2016in Journal of Macromolecular Science, Part A 1.06
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 6 AuthorsLindsey Miller4
Estimated H-index: 4
(University of Texas at Arlington)
ABSTRACTWe describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell line...
4 Citations Source Cite
Saira Jabeen5
Estimated H-index: 5
(Quaid-i-Azam University),
Ayesha Kausar20
Estimated H-index: 20
(Quaid-i-Azam University)
+ 2 AuthorsSagheer Gul4
Estimated H-index: 4
(Quaid-i-Azam University)
In this investigation, blends of poly(vinyl alcohol) and chitosan cross-linked with bis phenol-F-diglycidyl ether were prepared by solution casting method. Epoxy acted as a cross-linker and content was varied from 3.80 × 10−3 to 3.80 × 10−2 mol. Morphology of the blend was examined using scanning electron microscopy which showed homogenous morphology suggesting good miscibility between blend components. FTIR showed significant shifting of peak at 1063 cm−1 to higher frequency implying that inter...
4 Citations Source Cite
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Alicia Morrison2
Estimated H-index: 2
(Florida Atlantic University)
+ 3 AuthorsLindsey Miller4
Estimated H-index: 4
(University of Texas at Arlington)
4 Citations Source Cite
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 5 AuthorsPaul Slawek2
Estimated H-index: 2
(Florida Atlantic University)
Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS a...
2 Citations Source Cite
Published on Oct 1, 2018in Macromolecular Rapid Communications 4.44
Joji Tanaka4
Estimated H-index: 4
(University of Warwick),
Thomas P. Davis81
Estimated H-index: 81
(University of Warwick),
Paul Wilson35
Estimated H-index: 35
(University of Warwick)
2 Citations Source Cite