NOX2-derived reactive oxygen species are crucial for CD29-induced pro-survival signalling in cardiomyocytes.

Volume: 93, Issue: 3, Pages: 454 - 462
Published: Mar 1, 2012
Abstract
Aims The highly expressed cell adhesion receptor CD29 (β1-integrin) is essential for cardiomyocyte growth and survival, and its loss of function causes severe heart disease. However, CD29-induced signalling in cardiomyocytes is ill defined and may involve reactive oxygen species (ROS). A decisive source of cardiac ROS is the abundant NADPH oxidase (NOX) isoform NOX2. Because understanding of NOX-derived ROS in the heart is still poor, we sought...
Paper Details
Title
NOX2-derived reactive oxygen species are crucial for CD29-induced pro-survival signalling in cardiomyocytes.
Published Date
Mar 1, 2012
Volume
93
Issue
3
Pages
454 - 462
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