An Improved Fast Photochemical Oxidation of Proteins (FPOP) Platform for Protein Therapeutics

Volume: 26, Issue: 3, Pages: 526 - 529
Published: Mar 1, 2015
Abstract
Unlike small-molecule drugs, the size and dynamics of protein therapeutics challenge existing methods for assessing their high order structures (HOS). To extend fast photochemical oxidation of proteins (FPOP) to protein therapeutics, we modified its platform by introducing a mixing step prior to laser irradiation to minimize unwanted H2O2-induced oxidation. This improvement plus standardizing each step yield better reproducibility as determined...
Paper Details
Title
An Improved Fast Photochemical Oxidation of Proteins (FPOP) Platform for Protein Therapeutics
Published Date
Mar 1, 2015
Volume
26
Issue
3
Pages
526 - 529
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