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Influence of DMSO on the inhibition of various cancer cells by water-soluble organotin polyethers

Published on Dec 1, 2013in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2013.869481
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(Florida Atlantic University)
+ 1 AuthorsMichael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
Abstract
The effect of solvent on the ability to inhibit a group of cell lines was studied employing a series of water-soluble dibutyltin polyethers derived from various hydroxyl-terminated poly(ethylene glycols). Molecular weight as a function of time was essentially unchanged for a period of 30 weeks for the polyethers. Variations in test media can affect biological activities on the cell level as well as at the molecular level. The current study involves the evaluation of the cellular effects when dimethyl sulfoxide (DMSO) is initially employed to dissolve the polymers compared with using water alone to dissolve the polymer. Even though caution was taken to employ DMSO at concentrations where cell interactions are not found for the control, differences were found between samples exposed to DMSO and those not exposed to DMSO. The general inhibition fingerprint is similar for both conditions but the particular EC50 results can vary 10-fold. Thus, the presence of DMSO does have some effect on the particular biolog...
  • References (35)
  • Citations (10)
Cite
References35
Published on Jan 1, 2004in Journal of Polymer Materials 0.35
Ce Carraher1
Estimated H-index: 1
,
K Morie1
Estimated H-index: 1
8 Citations
Published on Jul 28, 2004
Charles E. Carraher24
Estimated H-index: 24
(Florida Atlantic University),
Deborah W. Siegmann-Louda2
Estimated H-index: 2
(Florida Atlantic University)
16 Citations Source Cite
Published on Feb 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
Poly[alkylene(arylene)oxystannanes] of the form below have been synthesized from dichlorostannanes and diols using a modified nonaqueous interfacial system consisting of acetonitrile and hydrocarbons. The products are preferentially capped with alcohol end-groups. Poly[alkylen(arylen)oxystannane] der folgenden Struktur wurden durch Grenzflachenpolykondensation von Dichlorstannen mit Diolen hergestellt. Dabei wurden modifizierte wasserfreie Losungsmittelsysteme aus Acetonitril und Kohlenwassersto...
25 Citations Source Cite
Published on Oct 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
The synthesis of some poly(tin ethers) according to the following route is described The number average polymerization degrees range from 78 to 1400. Die Synthese einiger Poly-(zinnather) wird beschrieben, und zwar durch die in der Summary wiedergegebene Reaktion. Die mittleren Polymerisationsgrade liegen im Bereich von 78 bis 1400.
28 Citations Source Cite
Published on Jan 1, 1999in Journal of Biochemical and Molecular Toxicology 1.84
Stanislav Forman1
Estimated H-index: 1
,
Jan K s1
Estimated H-index: 1
+ 2 AuthorsTom s Ruml1
Estimated H-index: 1
Testing of the effects of xenobiotics in cultured cells often requires the use of organic solvents to effect suspension of the test agents in cell culture media. However, the toxic effects of the solvents themselves may introduce artifacts, which obscure interpretation of the experimental results. In this article, the toxicity of different solvents commonly used for solvation of a variety of xenobiotic agents was studied. We show that ethanol, acetone, isooctane, methanol, and hexane were consid...
36 Citations Source Cite
Published on Jan 1, 1975in European Biophysics Journal 1.94
H. Wenzl1
Estimated H-index: 1
,
W. Lohmann1
Estimated H-index: 1
,
M. Hillerbrand1
Estimated H-index: 1
The interaction between Cu2+ and a few uracil derivatives has been investigated by means of electron spin resonance and optical absorption studies. It could be shown that a charge transfer interaction occurs. Its strength depends upon the electron attracting or releasing properties of the substituents of the nucleobase.
1 Citations Source Cite
Wajid Rehman14
Estimated H-index: 14
(Gomal University),
Musa Kaleem Baloch13
Estimated H-index: 13
(Gomal University)
+ 1 AuthorsSaqib Ali29
Estimated H-index: 29
(Quaid-i-Azam University)
Abstract The synthesis and characterization of new coordination compounds of some organotin(IV) chlorides with monomethyl phthalate is reported; the ligand molecules appear to be bound to the tin atom through carbonyl oxygen atoms. Their structures have been characterized by elemental analyses, molar conductance, and bonding in these complexes is discussed in terms of their IR, 1 H, 13 C, 119 Sn NMR and 119m Sn Mossbauer spectral studies. The spectroscopic results obtained are in full agreement ...
15 Citations Source Cite
Published on Oct 21, 2009in Materials 2.47
Charles E. Carraher24
Estimated H-index: 24
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synth...
24 Citations Source Cite
Charles E. Carraher24
Estimated H-index: 24
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 2 AuthorsGirish Barot11
Estimated H-index: 11
(Florida Atlantic University)
Organotin polyethers containing the synthetic estrogen diethylstilbestrol have been made in moderate yield with chain lengths ranging from 20 to 200 repeat units employing the interfacial polycondensation procedure. Infrared spectroscopy shows the absence of the O–H group and formation of the Sn–O linkage consistent with the formation of the polyether. F-MALDI MS results are consistent with the presence of organotin-containing fragmentation clusters containing one and two tin atoms and ion fragm...
23 Citations Source Cite
Published on Jul 1, 1976in Laryngoscope 2.44
Gordon R. Freeman2
Estimated H-index: 2
(University of California, San Diego)
The most controversial therapeutic agent in the past decade has been dimethylsulphoxide (DMSO), an industrial solvent to which great healing-powers have been attributed. After initial laboratory testing, DMSO was rapidly introduced into veterinarian medicine and clinical medicine as an experimental agent with the ability to relieve pain, reduce swelling and edema in trauma, to show anesthetic, antibacterial and anti-inflammatory properties when applied topically to the skin. Ninety percent DMSO§...
5 Citations Source Cite
Cited By10
Published on Nov 22, 2015in International Journal of Polymeric Materials 2.13
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 7 AuthorsZamil Islam1
Estimated H-index: 1
(Florida Atlantic University)
The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure/property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. A number of products ...
4 Citations Source Cite
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(Florida Atlantic University)
The efforts described in this paper are aimed at designing organotin polymers that control the growth of various cancers; here colorectal cancer and to identify structure/property relationships that will assist in this goal. The growth of colorectal cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 value is dependent on both the nature of the Lewis base and Lewis acid. EC50 values dow...
Source Cite
Charles E. Carraher24
Estimated H-index: 24
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(Florida Atlantic University)
The current efforts described in this paper are aimed at developing compounds that inhibit the growth of prostate cancer and to identify structure/property relationships that will further assist us towards this goal. The growth of prostate cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependant on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the picogra...
9 Citations Source Cite
Published on Feb 1, 2016in Journal of Macromolecular Science, Part A 1.06
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 3 AuthorsNandalall Sookdeo3
Estimated H-index: 3
(Florida Atlantic University)
ABSTRACTA wide variety of organotin polyethers derived from the interfacial polymerization of dibutyltin dichloride and non-cancer inhibitory diols show decent to good inhibition of two human pancreatic cancer cell lines. In view of the general lack of ability of tested compounds to inhibit pancreatic cancer cell lines, this is significant. These cell lines are the AsPC-1 pancreatic cancer cell line which is an adenocarcinoma pancreatic cell line and the PANC-1 pancreatic cancer cell line which ...
3 Citations Source Cite
Published on Jul 2, 2016in Journal of Macromolecular Science, Part A 1.06
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 6 AuthorsLindsey Miller4
Estimated H-index: 4
(University of Texas at Arlington)
ABSTRACTWe describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell line...
4 Citations Source Cite
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Alicia Morrison2
Estimated H-index: 2
(Florida Atlantic University)
+ 3 AuthorsLindsey Miller4
Estimated H-index: 4
(University of Texas at Arlington)
4 Citations Source Cite
Charles E. Carraher24
Estimated H-index: 24
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 4 AuthorsFloyd Russell3
Estimated H-index: 3
(Florida Atlantic University)
ABSTRACTThe initial synthesis of DMSO and water-soluble hafnocene polyethers is described. The polyethers are formed through reaction of the hafnocene dichloride with various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the hafnocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1200 to 8 with moderate product yield. They exhibit good inhibition of a variety of cance...
1 Citations Source Cite
Charles E. Carraher24
Estimated H-index: 24
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 5 AuthorsPaul Slawek2
Estimated H-index: 2
(Florida Atlantic University)
Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS a...
2 Citations Source Cite
Published on Sep 1, 2017
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 7 AuthorsFloyd Russell3
Estimated H-index: 3
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of ...
1 Citations Source Cite
Published on Jun 26, 2018
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 1 AuthorsFrancesca Mosca2
Estimated H-index: 2
Group 4 metallocene polymers offer a wide variety of unique properties. Some of these are reviewed in this paper, including the ability to form fibers and to absorb laser radiation, thereby protecting materials containing them in small amounts; the possibility of becoming conductive materials through simple doping; increasing the productivity of damaged, old and mold-infested seeds through incorporation of plant growth hormones; and acting as anticancer drugs that inhibit a variety of human canc...
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