Influence of DMSO on the inhibition of various cancer cells by water-soluble organotin polyethers
Published on Dec 1, 2013in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2013.869481
The effect of solvent on the ability to inhibit a group of cell lines was studied employing a series of water-soluble dibutyltin polyethers derived from various hydroxyl-terminated poly(ethylene glycols). Molecular weight as a function of time was essentially unchanged for a period of 30 weeks for the polyethers. Variations in test media can affect biological activities on the cell level as well as at the molecular level. The current study involves the evaluation of the cellular effects when dimethyl sulfoxide (DMSO) is initially employed to dissolve the polymers compared with using water alone to dissolve the polymer. Even though caution was taken to employ DMSO at concentrations where cell interactions are not found for the control, differences were found between samples exposed to DMSO and those not exposed to DMSO. The general inhibition fingerprint is similar for both conditions but the particular EC50 results can vary 10-fold. Thus, the presence of DMSO does have some effect on the particular biolog...