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Influence of DMSO on the inhibition of various cancer cells by water-soluble organotin polyethers

Published on Dec 1, 2013in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2013.869481
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University)
+ 1 AuthorsMichael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
Cite
Abstract
The effect of solvent on the ability to inhibit a group of cell lines was studied employing a series of water-soluble dibutyltin polyethers derived from various hydroxyl-terminated poly(ethylene glycols). Molecular weight as a function of time was essentially unchanged for a period of 30 weeks for the polyethers. Variations in test media can affect biological activities on the cell level as well as at the molecular level. The current study involves the evaluation of the cellular effects when dimethyl sulfoxide (DMSO) is initially employed to dissolve the polymers compared with using water alone to dissolve the polymer. Even though caution was taken to employ DMSO at concentrations where cell interactions are not found for the control, differences were found between samples exposed to DMSO and those not exposed to DMSO. The general inhibition fingerprint is similar for both conditions but the particular EC50 results can vary 10-fold. Thus, the presence of DMSO does have some effect on the particular biolog...
  • References (35)
  • Citations (10)
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References35
Newest
Published on Jul 1, 2011in Journal of Polymer Materials 0.41
Charles E. Carraher24
Estimated H-index: 24
,
Yoshinobu Naoshima12
Estimated H-index: 12
(Okayama University of Science)
+ 4 AuthorsAmitabh Battin6
Estimated H-index: 6
Published on May 27, 2011in Materials 2.97
Michael R. Roner19
Estimated H-index: 19
,
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very ...
Published on Apr 15, 2011in Materials 2.97
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less ...
Published on Oct 21, 2009in Materials 2.97
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synth...
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington),
Kimberly Shahi10
Estimated H-index: 10
(UTA: University of Texas at Arlington)
+ 2 AuthorsCharles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
Pancreatic cancer kills nearly all patients within 3–6 months after detection. There is no effective chemotherapy for it. We have found a number of organotin polymers that are effective at inhibiting pancreatic cancer cell lines with Chemotherapeutic Index values greater than two with some to values of 50.
Girish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 3 AuthorsCharles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
A variety of dibutyltin polyethers have been synthesized employing the interfacial polymerization technique. The products are polymers with degrees of polymerization ranging from 60 to 390. Infrared spectral and mass spectral results are consistent with the proposed structure. The products show good inhibition of a variety of cancer cells including those associated with bone, breast, prostrate, and lung cancers. Some also show good viral inhibition of the HSV-1 (herpes simplex) and Vaccina (smal...
Published on Apr 1, 2008in Journal of Polymer Materials 0.41
Anna Zhao3
Estimated H-index: 3
(UF: University of Florida),
Kimberly Shahi10
Estimated H-index: 10
(UTA: University of Texas at Arlington)
+ 6 AuthorsCharles E. Carraher24
Estimated H-index: 24
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 2 AuthorsGirish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University)
Organotin polyethers containing the synthetic estrogen diethylstilbestrol have been made in moderate yield with chain lengths ranging from 20 to 200 repeat units employing the interfacial polycondensation procedure. Infrared spectroscopy shows the absence of the O–H group and formation of the Sn–O linkage consistent with the formation of the polyether. F-MALDI MS results are consistent with the presence of organotin-containing fragmentation clusters containing one and two tin atoms and ion fragm...
Cited By10
Newest
Published on Jun 26, 2018
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 1 AuthorsFrancesca Mosca2
Estimated H-index: 2
Group 4 metallocene polymers offer a wide variety of unique properties. Some of these are reviewed in this paper, including the ability to form fibers and to absorb laser radiation, thereby protecting materials containing them in small amounts; the possibility of becoming conductive materials through simple doping; increasing the productivity of damaged, old and mold-infested seeds through incorporation of plant growth hormones; and acting as anticancer drugs that inhibit a variety of human canc...
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 5 AuthorsPaul Slawek2
Estimated H-index: 2
(FAU: Florida Atlantic University)
Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS a...
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 4 AuthorsFloyd Russell3
Estimated H-index: 3
(FAU: Florida Atlantic University)
ABSTRACTThe initial synthesis of DMSO and water-soluble hafnocene polyethers is described. The polyethers are formed through reaction of the hafnocene dichloride with various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the hafnocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1200 to 8 with moderate product yield. They exhibit good inhibition of a variety of cance...
Published on Sep 1, 2017
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 7 AuthorsFloyd Russell3
Estimated H-index: 3
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of ...
Published on Jul 2, 2016in Journal of Macromolecular Science, Part A 1.16
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 6 AuthorsLindsey Miller4
Estimated H-index: 4
(UTA: University of Texas at Arlington)
ABSTRACTWe describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell line...
Published on Feb 1, 2016in Journal of Macromolecular Science, Part A 1.16
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 3 AuthorsNandalall Sookdeo3
Estimated H-index: 3
(FAU: Florida Atlantic University)
ABSTRACTA wide variety of organotin polyethers derived from the interfacial polymerization of dibutyltin dichloride and non-cancer inhibitory diols show decent to good inhibition of two human pancreatic cancer cell lines. In view of the general lack of ability of tested compounds to inhibit pancreatic cancer cell lines, this is significant. These cell lines are the AsPC-1 pancreatic cancer cell line which is an adenocarcinoma pancreatic cell line and the PANC-1 pancreatic cancer cell line which ...
Published on Nov 22, 2015in International Journal of Polymeric Materials 2.26
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 7 AuthorsZamil Islam1
Estimated H-index: 1
(FAU: Florida Atlantic University)
The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure/property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. A number of products ...
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Alicia Morrison2
Estimated H-index: 2
(FAU: Florida Atlantic University)
+ 3 AuthorsLindsey Miller4
Estimated H-index: 4
(UTA: University of Texas at Arlington)
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(FAU: Florida Atlantic University)
The current efforts described in this paper are aimed at developing compounds that inhibit the growth of prostate cancer and to identify structure/property relationships that will further assist us towards this goal. The growth of prostate cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependant on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the picogra...
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(FAU: Florida Atlantic University)
The efforts described in this paper are aimed at designing organotin polymers that control the growth of various cancers; here colorectal cancer and to identify structure/property relationships that will assist in this goal. The growth of colorectal cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 value is dependent on both the nature of the Lewis base and Lewis acid. EC50 values dow...