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Biologic Enhancement of Wound Healing
Published on Oct 1, 2007in Clinics in Plastic Surgery 2.02
· DOI :10.1016/j.cps.2007.07.001
Paul J. Leahy2
Estimated H-index: 2
(University of Kansas),
W.Thomas Lawrence2
Estimated H-index: 2
(University of Kansas)
Abstract
Manipulation of the healing process through wound supplementation with agents that are natural contributors to the healing process is an appealing concept. Early experimental studies evaluating wounds supplemented with inflammatory mediators used materials extracted from cell preparations and generated encouraging results. Recombinant technology has allowed the production of larger volumes of these mediators that can be used more practically and safely in the clinical setting. Several clinical trials involving inflammatory mediators as wound supplements are reviewed, and the results of many of the studies are encouraging. Wound supplements are considered drugs, and therefore, they must be demonstrated to be safe and efficacious before they can receive approval for human use by the FDA. It is extremely expensive to carry out the experimental studies required for FDA approval. Because of the expense involved, Regranex is the only supplement that has been tested thoroughly enough to receive FDA approval for use in humans. It is hoped that additional agents will be demonstrated to be safe and efficacious in human trials so that they might become available in the United States in the near future.
  • References (72)
  • Cited By (14)
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References72
Published on Dec 1, 1994in American Journal of Pathology 4.07
G. F. Pierce2
Estimated H-index: 2
,
J. E. Tarpley2
Estimated H-index: 2
+ 5 AuthorsJ. S. Vande Berg3
Estimated H-index: 3
Abstract Cellular and molecular mechanisms responsible for the observed vulnerary effects of recombinant human platelet-derived growth factor BB (rP-DGF-BB) in man have not been elucidated. In a double-blinded trial, patients having chronic pressure ulcers were treated topically with either rPDGF-BB or placebo for 28 days. To explore how rPDGF-BB may induce chronic wounds to heal, biopsies were taken from the ulcers of a cohort of 20 patients from the trial and evaluated in a blinded fashion by ...
84 Citations
Published on Sep 1, 1990in Surgery 3.57
Atri Sc1
Estimated H-index: 1
,
Misra J1
Estimated H-index: 1
+ 1 AuthorsMisra K1
Estimated H-index: 1
71 Citations
Published on Aug 1, 1993in Surgery 3.57
Kirk Sj3
Estimated H-index: 3
,
Hurson M3
Estimated H-index: 3
+ 3 AuthorsAdrian Barbul53
Estimated H-index: 53
Background. Experimentally, arginine enhances immune function and promotes wound healing. In this randomized double-blind study we investigated the effect of oral arginine supplementation on wound healing and T-cell function in elderly human beings (more than 65 years of age). Methods. Thirty elderly, healthy, human volunteers (75 men and 75 women) received daily supplements of 30 gm arginine aspartate (17 gm free arginine). Fifteen volunteers (nine men and six women) received a placebo syrup. F...
280 Citations
Published on Jul 1, 1999in Orthopedics 1.46
Riedel Ge1
Estimated H-index: 1
,
Valentin-Opran A1
Estimated H-index: 1
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive protein that plays a pivotal role in bone growth and regeneration. Studies conducted in many mammalian species and, most recently, human clinical studies, have provided definitive evidence of the ability of rhBMP-2 to induce bone. The findings of these studies provide a rationale for investigating whether rhBMP-2 therapy will be clinically useful in orthopedic practice. Consequently, we have initiated a clinical resear...
68 Citations Source Cite
Hongwei Cheng11
Estimated H-index: 11
,
Wei Jiang30
Estimated H-index: 30
+ 10 AuthorsPantila Vanichakarn4
Estimated H-index: 4
Background: Bone morphogenic proteins (BMPs) are known to promote osteogenesis, and clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture-healing and spinal fusion. The optimal BMPs to be used in different clinical applications have not been elucidated, and a comprehensive evaluation of the relative osteogenic activity of different BMPs is lacking. Methods: To identify the BMPs that may possess the most osteoinductive activity, we analyzed the osteoge...
727 Citations Source Cite
Published on Apr 1, 2006in Annals of Plastic Surgery 1.54
Joon Pio Hong19
Estimated H-index: 19
,
Heun Don Jung3
Estimated H-index: 3
,
Yun Wha Kim2
Estimated H-index: 2
Abstract: This paper studies the healing effect of recombinant human epidermal growth factor (EGF) on chronic diabetic foot ulcers. A total of 89 patients (65 male and 24 female) aged from 36 to 82 years (average of 54) enrolled for the prospective, open-label trial, crossover study. Predetermined criteria were used for diagnosis and classification of ulcer. The average duration of ulcer was 6 months (range from 3 to 27 months) prior to study. Upon study, the ulcers were debrided and treated wit...
80 Citations Source Cite
Published on May 1, 1990in Journal of Investigative Dermatology 6.45
Lillian B. Nanney49
Estimated H-index: 49
Epidermal growth factor (EGF), a well-characterized peptide that stimulates in vitro cell proliferation, has now been shown to enhance in vivo resurfacing of porcine wounds. Topical formulations containing either recombinant EGF or placebo were applied daily to partial-thickness wounds along the dorsal surface of pigs. Following full-thickness removal of these wounds, tissues were sectioned and stained, and histologic sections were subjected to computerized morphometric analysis. A significant a...
155 Citations Source Cite
Published on Sep 1, 2000in Journal of Parenteral and Enteral Nutrition 4.25
Bobbi Langkamp-Henken19
Estimated H-index: 19
,
Kelli A. Herrlinger-Garcia10
Estimated H-index: 10
+ 3 AuthorsLaura Moffatt1
Estimated H-index: 1
Background: Immune function declines with age, increasing risk for infection and delaying wound healing. Arginine enhances immune function and healing of standardized wounds in healthy elderly persons. The purpose of this study was to determine what level of arginine supplementation was orally and metabolically tolerated and effective in enhancing immune function in elderly persons with pressure ulcers. Methods: Residents with one or more pressure ulcers were recruited from two local nursing hom...
46 Citations Source Cite
Published on Nov 12, 1965in Science 41.06
Marshall R. Urist60
Estimated H-index: 60
(University of California, Los Angeles)
Wandering histiocytes, foreign body giant cells, and inflammatory connective-tissue cells are stimulated by degradation products of dead matrix to grow in and repopulate the area of an implant of decalcified bone. Histiocytes are more numerous than any other cell form and may transfer collagenolytic activity to the substrate to cause dissolution of the matrix. The process is followed immediately by new-bone formation by autoinduction in which both the inductor cells and the induced cells are der...
4,379 Citations Source Cite
Cited By14
Published on Jul 1, 2012in Advances in Skin & Wound Care 1.38
Tatiana N. Demidova-Rice8
Estimated H-index: 8
,
Michael R. Hamblin77
Estimated H-index: 77
,
Ira M. Herman41
Estimated H-index: 41
(Tufts University)
This is the first installment of 2 articles that discuss the biology and pathophysiology of wound healing, review the role that growth factors play in this process, and describe current ways of growth factor delivery into the wound bed. Part 1 discusses the latest advances in clinicians’ understanding of the control points that regulate wound healing. Importantly, biological similarities and differences between acute and chronic wounds are considered, including the signaling pathways that initia...
134 Citations Source Cite
Published on Aug 1, 2012in Advances in Skin & Wound Care 1.38
Tatiana N. Demidova-Rice8
Estimated H-index: 8
,
Michael R. Hamblin77
Estimated H-index: 77
,
Ira M. Herman41
Estimated H-index: 41
This is the second of 2 articles that discuss the biology and pathophysiology of wound healing, reviewing the role that growth factors play in this process and describing the current methods for growth factor delivery into the wound bed.
60 Citations Source Cite
Published on Jan 1, 2015in Cellular Physiology and Biochemistry 5.50
Bizunesh Mideksa Borena5
Estimated H-index: 5
,
Ann Martens20
Estimated H-index: 20
+ 4 AuthorsJan H. Spaas11
Estimated H-index: 11
Mammal skin has a crucial function in several life-preserving processes such as hydration, protection against chemicals and pathogens, initialization of vitamin D synthesis, excretion and heat regulation. Severe damage of the skin may therefore be life-threatening. Skin wound repair is a multiphased, yet well-orchestrated process including the interaction of various cell types, growth factors and cytokines aiming at closure of the skin and preferably resulting in tissue repair. Regardless variou...
43 Citations Source Cite
Published on Mar 1, 2013in Bulletin of Experimental Biology and Medicine 0.55
A. K. Kirichenko1
Estimated H-index: 1
,
I. N. Bolshakov1
Estimated H-index: 1
+ 1 AuthorsA. A. Vlasov1
Estimated H-index: 1
12 Citations Source Cite
Published on Feb 1, 2012in Advances in wound care
Tatiana N. Demidova-Rice8
Estimated H-index: 8
,
Jennifer T. Durham8
Estimated H-index: 8
,
Ira M. Herman41
Estimated H-index: 41
Background: Formation of new blood vessels, by either angiogenesis or vasculogenesis, is critical for normal wound healing. Major processes in neovascularization include (i) growth-promoting or survival factors, (ii) proteolytic enzymes, (iii) activators of multiple differentiated and progenitor cell types, and (iv) permissible microenvironments. A central aim of wound healing research is to “convert” chronic, disease-impaired wounds into those that will heal. The problem: Reduced ability to re-...
36 Citations Source Cite
Published on Apr 1, 2011in International Wound Journal 2.38
Giulio Gualdi6
Estimated H-index: 6
,
Paola Monari6
Estimated H-index: 6
+ 1 AuthorsPiergiacomo Calzavara-Pinton31
Estimated H-index: 31
It is well shown that chronic wounds are populated by cells unable to respond to re-epithelising stimulus. Large ulcers that remain unhealed for several months are more difficult to treat probably because of the depletion of active factors. Yet in 1869 Reverdin realised that the partial coverage of an ulcer with small fragments of healthy skin was able to lead to wound healing; unfortunately, its employment was limited to granulating wounds. Recently, the importance of factors such as cytokines,...
2 Citations Source Cite
Published on Mar 1, 2012in Obesity Surgery 3.89
Rodolpho Alberto Bussolaro4
Estimated H-index: 4
(Federal University of São Paulo),
Elvio Bueno Garcia12
Estimated H-index: 12
(Federal University of São Paulo)
+ 1 AuthorsLydia Masako Ferreira30
Estimated H-index: 30
(Federal University of São Paulo)
Background Bariatric surgery reduces body weight, but creates the need for surgical correction of the patient’s body shape, especially of the abdomen. The abdominal skin of the ex-obese has a lower quantity of fibrous and non-fibrous components; however, its functional status has not yet been studied. This study quantified, at different depths, the neurological function of the abdominal skin of the obese and morbidly ex-obese.
4 Citations Source Cite
Published on Aug 1, 2009in Medical Journal of Indonesia
Theddeus O.H. Prasetyono5
Estimated H-index: 5
Wound healing is a transition of processes which is also recognized as one of the most complex processes in human physiology. Complex series of reactions and interactions among cells and mediators take place in the healing process of wound involving cellular and molecular events. The inflammatory phase is naturally intended to remove devitalized tissue and prevent invasive infection. The proliferative phase is characterized by the formation of granulation tissue within the wound bed, composed of...
2 Citations Source Cite
Published on Jun 1, 2008in Journal of Investigative Dermatology 6.45
Jeffrey M. Davidson56
Estimated H-index: 56
(Vanderbilt University)
Growth factor bioavailability in therapeutic applications such as wound healing is limited by extracellular matrix sequestration, proteolysis, and clearance. Local, transient delivery by gene transfer is an attractive concept. Many transfection strategies are available, and adenoviral vectors are in clinical trials. Keratinocyte growth factor-1 (KGF-1), an epithelial-specific member of the fibroblast growth factor (FGF) family, has achieved limited success in protein formulations. Matrix- and ce...
15 Citations Source Cite
Published on Jan 1, 2010
Vijayeta Rangarajan1
Estimated H-index: 1
,
Frank Dreher1
Estimated H-index: 1
Growth factors are polypeptides or proteins, which play a key role in the regulation of a number of physiological processes operating at extremely low concentrations [1]. Together with cytokines, they are important regulators of cell division, differentiation, chemotaxis and adhesion, cellular trafficking, cell activation, apoptosis, cell survival, and transformation. They typically mediate interactions between cells within a specific tissue microenvironment, thereby, binding its corresponding r...
2 Citations
View next paperRandomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers.