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Biologic Enhancement of Wound Healing

Published on Oct 1, 2007in Clinics in Plastic Surgery 2.02
· DOI :10.1016/j.cps.2007.07.001
Paul J. Leahy2
Estimated H-index: 2
(University of Kansas),
W.Thomas Lawrence3
Estimated H-index: 3
(University of Kansas)
Abstract
Manipulation of the healing process through wound supplementation with agents that are natural contributors to the healing process is an appealing concept. Early experimental studies evaluating wounds supplemented with inflammatory mediators used materials extracted from cell preparations and generated encouraging results. Recombinant technology has allowed the production of larger volumes of these mediators that can be used more practically and safely in the clinical setting. Several clinical trials involving inflammatory mediators as wound supplements are reviewed, and the results of many of the studies are encouraging. Wound supplements are considered drugs, and therefore, they must be demonstrated to be safe and efficacious before they can receive approval for human use by the FDA. It is extremely expensive to carry out the experimental studies required for FDA approval. Because of the expense involved, Regranex is the only supplement that has been tested thoroughly enough to receive FDA approval for use in humans. It is hoped that additional agents will be demonstrated to be safe and efficacious in human trials so that they might become available in the United States in the near future.
  • References (72)
  • Citations (13)
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References72
Newest
Published on Sep 1, 2006in International Wound Journal 2.38
Markus Streit12
Estimated H-index: 12
,
Zsuzsanna Beleznay1
Estimated H-index: 1
,
Lasse R. Braathen39
Estimated H-index: 39
The role of tumour necrosis factor-alpha (TNF-α) in wound healing is not clear. Elevated levels of TNF-α have been observed in fluids from chronic wounds and have been shown to decrease over time during the healing process. Therapeutic antibodies such as infliximab can inhibit TNF-α activity. In this case series, we applied infliximab topically to eight patients with chronic ulcers of more than 4-month durations. The ulcers had multifactorial aetiology, with chronic venous insufficiency being th...
74 Citations Source Cite
Published on Jun 1, 2006in Plastic and Reconstructive Surgery 3.62
George Broughton8
Estimated H-index: 8
,
Jeffrey E. Janis32
Estimated H-index: 32
,
Christopher E. Attinger36
Estimated H-index: 36
Summary:Since the caveman, man has been tending to his wounds. Wound care evolved from magical incantations, potions, and ointments, to a systematic text of wound care and surgery from Hippocrates and Celsus. These advances were lost after the fall of the Roman Empire. In Europe, the Middle Ages wer
55 Citations Source Cite
Published on Jun 1, 2006in Plastic and Reconstructive Surgery 3.62
David L. Steed1
Estimated H-index: 1
Background: Diabetic foot ulcer is a major health care problem that leads to amputation. Methods: Patients with full-thickness diabetic neurotrophic foot ulcers present for longer than 8 weeks without healing were entered into one of five randomized, prospective, blinded clinical trials comparing treatment with platelet-derived growth factor (PDGF) or placebo gel for up to 20 weeks. The purpose of these trials was to assess the safety and efficacy of PDGF used with good wound care. Each patient ...
155 Citations Source Cite
Published on Jun 1, 2006in Plastic and Reconstructive Surgery 3.62
George Broughton8
Estimated H-index: 8
,
Jeffrey E. Janis32
Estimated H-index: 32
,
Christopher E. Attinger36
Estimated H-index: 36
Summary:Understanding wound healing today involves much more than simply stating that there are three phases: “inflammation, proliferation, and maturation.” Wound healing is a complex series of reactions and interactions among cells and “mediators.” Each year, new mediators are discovered and our un
644 Citations Source Cite
Published on Jun 1, 2006in Plastic and Reconstructive Surgery 3.62
Christopher E. Attinger36
Estimated H-index: 36
(Georgetown University),
Jeffrey E. Janis32
Estimated H-index: 32
+ 3 AuthorsKara Couch3
Estimated H-index: 3
Summary:This is a clinical review of current techniques in wound bed preparation found to be effective in assisting the wound-healing process. The process begins with the identification of a correct diagnosis of the wound’s etiology and continues with optimizing the patient’s medical condition, incl
165 Citations Source Cite
Published on May 22, 2006in FEBS Letters 3.00
Himadri Roy11
Estimated H-index: 11
,
Shalini Bhardwaj12
Estimated H-index: 12
,
Seppo Ylä-Herttuala92
Estimated H-index: 92
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenes...
375 Citations Source Cite
Published on Apr 1, 2006in Annals of Plastic Surgery 1.54
Joon Pio Hong33
Estimated H-index: 33
,
Heun Don Jung3
Estimated H-index: 3
,
Yun Wha Kim2
Estimated H-index: 2
Abstract: This paper studies the healing effect of recombinant human epidermal growth factor (EGF) on chronic diabetic foot ulcers. A total of 89 patients (65 male and 24 female) aged from 36 to 82 years (average of 54) enrolled for the prospective, open-label trial, crossover study. Predetermined criteria were used for diagnosis and classification of ulcer. The average duration of ulcer was 6 months (range from 3 to 27 months) prior to study. Upon study, the ulcers were debrided and treated wit...
81 Citations Source Cite
Published on Jan 1, 2006in British Journal of Dermatology 6.13
Francesca Cianfarani16
Estimated H-index: 16
,
R. Tommasi1
Estimated H-index: 1
+ 5 AuthorsTeresa Odorisio19
Estimated H-index: 19
Summary Background Granulocyte/macrophage colony-stimulating factor (GM-CSF), a cytokine with pleiotropic functions, has been successfully employed in the treatment of chronic skin ulcers. The biological effects underlying GM-CSF action in impaired wound healing have been only partly clarified. Objectives To investigate the effects of GM-CSF treatment of chronic venous ulcers on lesion vascularization and on the local synthesis of the angiogenic factors vascular endothelial growth factor (VEGF) ...
61 Citations Source Cite
Published on Jan 1, 2006in Plastic and Reconstructive Surgery 3.62
Ali Al-Attar15
Estimated H-index: 15
,
Sarah Mess3
Estimated H-index: 3
+ 2 AuthorsSteven P. Davison19
Estimated H-index: 19
Background:Keloid management can be difficult and frustrating, and the mechanisms underlying keloid formation are only partially understood.Methods:Using original and current literature in this field, this comprehensive review presents the major concepts of keloid pathogenesis and the treatment opti
326 Citations Source Cite
Published on Nov 1, 2005in Burns 2.13
Sadanori Akita22
Estimated H-index: 22
(Nagasaki University),
Kozo Akino21
Estimated H-index: 21
(Nagasaki University)
+ 1 AuthorsAkiyoshi Hirano25
Estimated H-index: 25
(Nagasaki University)
Abstract To avoid hypertrophic scars in burn wounds, the simultaneous application of basic fibroblast growth factor (bFGF) with regular surgical debridement and skin grafting was investigated for skin hardness by clinical examination and instrumental measurement. As little is known about the role of bFGF in wounds, burn wound scars were tested for hardness. Burn scars in various anatomical locations at least 1 year after final wound healing clinically demonstrated a significantly lower hard scor...
79 Citations Source Cite
Cited By13
Newest
Published on Jan 1, 2018
Bruce A. Kraemer (Saint Louis University)
Wounds of the distal third of the leg, ankle, and foot are difficult reconstructive problems due to the involvement of the adjacent bone and tendons within the wound and the frequent absence of suitable local available tissue to close the wound. The orthopedic management of distal leg fractures has evolved greatly over the last 35 years, while the standard wound closure techniques have remained relatively static. With the orthopedist’s greater respect for the overall biology of the distal leg ti...
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Published on Jan 1, 2015in Cellular Physiology and Biochemistry 5.50
Bizunesh Mideksa Borena6
Estimated H-index: 6
,
Ann Martens20
Estimated H-index: 20
+ 4 AuthorsJan H. Spaas11
Estimated H-index: 11
Mammal skin has a crucial function in several life-preserving processes such as hydration, protection against chemicals and pathogens, initialization of vitamin D synthesis, excretion and heat regulation. Severe damage of the skin may therefore be life-threatening. Skin wound repair is a multiphased, yet well-orchestrated process including the interaction of various cell types, growth factors and cytokines aiming at closure of the skin and preferably resulting in tissue repair. Regardless variou...
47 Citations Source Cite
Published on Mar 1, 2014in International Journal of Pharmaceutics 3.86
Serban Bertesteanu4
Estimated H-index: 4
(Carol Davila University of Medicine and Pharmacy),
Stefanos Triaridis18
Estimated H-index: 18
(Aristotle University of Thessaloniki)
+ 4 AuthorsRaluca Grigore5
Estimated H-index: 5
(Carol Davila University of Medicine and Pharmacy)
Abstract Acute and chronic wounds represent a very common health problem in the entire world. The dermal wounds are colonized by aerobic and anaerobic bacterial and fungal strains, most of them belonging to the resident microbiota of the surrounding skin, oral cavity and gut, or from the external environment, forming polymicrobial communities called biofilms, which are prevalent especially in chronic wounds. A better understanding of the precise mechanisms by which microbial biofilms delay repai...
34 Citations Source Cite
Published on Mar 1, 2013in Bulletin of Experimental Biology and Medicine 0.55
A. K. Kirichenko1
Estimated H-index: 1
,
I. N. Bolshakov1
Estimated H-index: 1
+ 1 AuthorsA. A. Vlasov1
Estimated H-index: 1
13 Citations Source Cite
Published on Aug 1, 2012in Advances in Skin & Wound Care 1.38
Tatiana N. Demidova-Rice9
Estimated H-index: 9
,
Michael R. Hamblin78
Estimated H-index: 78
,
Ira M. Herman43
Estimated H-index: 43
This is the second of 2 articles that discuss the biology and pathophysiology of wound healing, reviewing the role that growth factors play in this process and describing the current methods for growth factor delivery into the wound bed.
64 Citations Source Cite
Published on Mar 1, 2012in Obesity Surgery 3.89
Rodolpho Alberto Bussolaro4
Estimated H-index: 4
(Federal University of São Paulo),
Elvio Bueno Garcia13
Estimated H-index: 13
(Federal University of São Paulo)
+ 1 AuthorsLydia Masako Ferreira28
Estimated H-index: 28
(Federal University of São Paulo)
Background Bariatric surgery reduces body weight, but creates the need for surgical correction of the patient’s body shape, especially of the abdomen. The abdominal skin of the ex-obese has a lower quantity of fibrous and non-fibrous components; however, its functional status has not yet been studied. This study quantified, at different depths, the neurological function of the abdominal skin of the obese and morbidly ex-obese.
4 Citations Source Cite
Published on Feb 1, 2012in Advances in wound care
Tatiana N. Demidova-Rice9
Estimated H-index: 9
,
Jennifer T. Durham8
Estimated H-index: 8
,
Ira M. Herman43
Estimated H-index: 43
Background: Formation of new blood vessels, by either angiogenesis or vasculogenesis, is critical for normal wound healing. Major processes in neovascularization include (i) growth-promoting or survival factors, (ii) proteolytic enzymes, (iii) activators of multiple differentiated and progenitor cell types, and (iv) permissible microenvironments. A central aim of wound healing research is to “convert” chronic, disease-impaired wounds into those that will heal. The problem: Reduced ability to re-...
39 Citations Source Cite
Published on Apr 1, 2011in International Wound Journal 2.38
Giulio Gualdi7
Estimated H-index: 7
,
Paola Monari7
Estimated H-index: 7
+ 1 AuthorsPiergiacomo Calzavara-Pinton32
Estimated H-index: 32
It is well shown that chronic wounds are populated by cells unable to respond to re-epithelising stimulus. Large ulcers that remain unhealed for several months are more difficult to treat probably because of the depletion of active factors. Yet in 1869 Reverdin realised that the partial coverage of an ulcer with small fragments of healthy skin was able to lead to wound healing; unfortunately, its employment was limited to granulating wounds. Recently, the importance of factors such as cytokines,...
2 Citations Source Cite
Published on Apr 1, 2011in Ostomy Wound Management 0.99
Michael P. Kurtz8
Estimated H-index: 8
,
Erik Svensson2
Estimated H-index: 2
,
Tomas M. Heimann25
Estimated H-index: 25
Abdominoperineal resection (APR) is the operative procedure of choice in patients with anorectal complications of inflammatory bowel disease (IBD) where a restorative proctocolectomy is either undesirable or impossible to perform. The challenge in these patients is poor perineal wound healing. A retrospective chart review was conducted of 118 patients (average age 44 years, range 28–73) with intractable IBD who underwent APR to evaluate perineal wound healing outcomes. Fortyfour (44) had Crohn’s...
2 Citations
Published on May 6, 2010
Frcp Consultant Dermatologist J. E. Mellerio BSc1
Estimated H-index: 1
(St Thomas' Hospital)
2 Citations Source Cite