Minor-Groove Binding Drugs: Where Is the Second Hoechst 33258 Molecule?

Volume: 117, Issue: 19, Pages: 5820 - 5830
Published: May 6, 2013
Abstract
Hoechst 33258 binds with high affinity into the minor groove of AT-rich sequences of double-helical DNA. Despite extensive studies of this and analogous DNA binding molecules, there still remains uncertainty concerning the interactions when multiple ligand molecules are accommodated within close distance. Albeit not of direct concern for most biomedical applications, which are at low drug concentrations, interaction studies for higher drug...
Paper Details
Title
Minor-Groove Binding Drugs: Where Is the Second Hoechst 33258 Molecule?
Published Date
May 6, 2013
Journal
Volume
117
Issue
19
Pages
5820 - 5830
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