Optimization of ferric chloride induced thrombosis model in rats: Effect of anti-platelet and anti-coagulant drugs

Numerous studies on various animal species, with variability in the site of application and the concentration of ferric chloride (FeCl3) to induce intravascular thrombosis has prompted us to undertake the present study to obtain a threshold concentration of FeCl3 and validate this model by clinically used anti-thrombotic drugs. A small piece of filter paper, soaked in FeCl3 solution (10, 20, 40, 60 or 80%, w/v), was topically applied on the...