Match!

Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?

Published on Dec 1, 2000in Current Opinion in Lipidology4.844
· DOI :10.1097/00041433-200012000-00010
von Eckardstein A2
Estimated H-index: 2
,
Gerd Assmann Frcp87
Estimated H-index: 87
Abstract
Consistent with several potentially anti-atherogenic activities of high-density lipoproteins in vitro, low plasma levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease. In addition to genes, lifestyle factors (e.g. smoking, being overweight an
  • References (114)
  • Citations (93)
📖 Papers frequently viewed together
588 Citations
3,052 Citations
1,346 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References114
Newest
#1Klaus A. DugiH-Index: 16
#2Karin BrandauerH-Index: 3
Last. Joerg KreuzerH-Index: 8
view all 13 authors...
Background— The crucial function of hepatic lipase (HL) in lipid metabolism has been well established, but the relationship between HL activity and coronary artery disease (CAD) is disputed. Methods and Results— We measured HL activity in the postheparin plasma of 200 consecutive men undergoing elective coronary angiography and determined the degree of CAD with the extent score, which has been shown to be better correlated with known risk factors than other measures of CAD extent. We found a sig...
96 CitationsSource
#1Anne Tailleux (Rhône-Poulenc)H-Index: 33
#2Muriel Bouly (Rhône-Poulenc)H-Index: 1
Last. Catherine Fievet (Rhône-Poulenc)H-Index: 45
view all 10 authors...
Abstract —Studies performed in vivo have been controversial regarding the implication of human apolipoprotein (apo)A-II in the atherogenic process. Expression of human apoA-II in transgenic mice fed a chow diet leads to (1) a bimodal distribution of high density lipoprotein (HDL) size as in humans, (2) a reduction in total cholesterol concentration that is mainly due to a reduction in non–HDL cholesterol level, and (3) a dramatic reduction in mouse endogenous apoA-I and apoA-II. After 20 weeks o...
45 CitationsSource
#1Joyce J. Repa (HHMI: Howard Hughes Medical Institute)H-Index: 51
#2Stephen D. Turley (UTSW: University of Texas Southwestern Medical Center)H-Index: 35
Last. David J. Mangelsdorf (HHMI: Howard Hughes Medical Institute)H-Index: 115
view all 10 authors...
Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids. Animals treated with rexinoids exhibited marked changes in cholesterol balance, including inhibition of cholesterol absorption and repressed bile acid synthesis. Studies with receptor-selective agonists revealed that oxysterol receptors (LXRs) and the bile acid receptor (FXR) are the RXR heterodimeric partners that mediate...
1,105 CitationsSource
The ABCA1 gene, a member of the ATP-binding cassette A (ABCA1) transporter superfamily, encodes a membrane protein that facilitates the cellular efflux of cholesterol and phospholipids. Mutations in ABCA1 lead to familial high density lipoprotein deficiency and Tangier disease. We report the complete human ABCA1 gene sequence, including 1,453 bp of the promoter, 146,581 bp of introns and exons, and 1 kb of the 3′ flanking region. The ABCA1 gene spans 149 kb and comprises 50 exons. Sixty-two repe...
184 CitationsSource
BACKGROUND: Coronary heart disease patients with low high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride levels, or both are at an increased risk of cardiovascular events, but the clinical impact of raising HDL-C or decreasing triglycerides remains to be confirmed. METHODS AND RESULTS: In a double-blind trial, 3090 patients with a previous myocardial infarction or stable angina, total cholesterol of 180 to 250 mg/dL, HDL-C or =200 mg/dL), the reduction in the cumulative probab...
898 Citations
#1Klaus A. Dugi (Heidelberg University)H-Index: 16
#2Karin Brandauer (Heidelberg University)H-Index: 3
Last. Jörg Kreuzer (Heidelberg University)H-Index: 28
view all 5 authors...
3 CitationsSource
#1Philippe Costet (Columbia University)H-Index: 4
#2Yi Luo (Columbia University)H-Index: 7
Last. Alan R. Tall (Columbia University)H-Index: 114
view all 4 authors...
Abstract Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding cassette transporter ABC1. In cultured macrophages, ABC1 mRNA was induced in an additive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid (9CRA), suggesting induction by nuclear hormone receptors of the liver X receptor (LXR) and retinoid X receptor (RXR) family. We cloned the 5′-end of the human ABC1 trans...
820 CitationsSource
#1Yannick Hamon (French Institute of Health and Medical Research)H-Index: 15
#2Cyril Broccardo (French Institute of Health and Medical Research)H-Index: 13
Last. Giovanna Chimini (French Institute of Health and Medical Research)H-Index: 39
view all 11 authors...
ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.
461 CitationsSource
#1Claus LangerH-Index: 17
#2Yadong HuangH-Index: 55
Last. A. von EckardsteinH-Index: 73
view all 7 authors...
We investigated the effect of endogenous apolipoprotein (apo) E synthesis in mouse peritoneal macrophages on cholesterol efflux and intracellular cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 (HDL3) and lipid-free apolipoproteins (apo). After loading with acetylated LDL (acLDL) peritoneal macrophages from wild-type (apoE+/+) and apoE-deficient (apoE–/–) mice were incubated with medium alone or with liposomes, HDL3, lipid-free apoA-I, or lipid-free apoE3. Cholesterol and cho...
64 CitationsSource
#1Julian B. MarshH-Index: 6
#2Francine K. WeltyH-Index: 37
Last. Ernst J. SchaeferH-Index: 119
view all 3 authors...
Amino acid precursors labelled with stable isotopes have been successfully used to explore the metabolism of the apolipoproteins of HDL. Some methodological and mathematical modelling problems remain, mainly related to amino acid recycling in a plasma protein such as apolipoprotein A-I with a long residence time (the reciprocal of the fractional catabolic rate) of 4-5 days. Apolipoprotein A-I, apolipoprotein E, and apolipoprotein A-IV in triglyceride-rich lipoproteins (containing chylomicrons, V...
37 CitationsSource
Cited By93
Newest
#1Kuen-Ming Wu (Jen-Ai Hospital)H-Index: 1
#2Yuan-Man Hsu (PRC: China Medical University (PRC))H-Index: 19
Last. Chih Yang Huang (PRC: China Medical University (PRC))H-Index: 40
view all 13 authors...
High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development of heart failure and diabetic cardiomyopathy. High-density lipoprotein (HDL) has been reported to possess key atheroprotective biological properties, including cellular cholesterol efflux capacity, anti-oxidative and anti-inflammatory activities. However, the underlying mechanisms are stil...
2 CitationsSource
#1Nathan F. Johnson (UK: University of Kentucky)H-Index: 13
#2Brian T. Gold (UK: University of Kentucky)H-Index: 28
Last. David K. Powell (UK: University of Kentucky)H-Index: 17
view all 8 authors...
A growing body of evidence indicates that biomarkers of cardiovascular risk may be related to cerebral health. However, little is known about the role non-fasting lipoprotein play in assessing age-related declines in a cerebral biomarker sensitive to vascular compromise, white matter (WM) microstructure. High-density lipoprotein cholesterol (HDL-C) is atheroprotective and low-density lipoprotein cholesterol (LDL-C) is a major atherogenic lipoprotein. This study explored the relationships between...
Source
#1Yuichi Ozaki (Wakayama Medical University)H-Index: 17
#2Atsushi Tanaka (Wakayama Medical University)H-Index: 39
Last. Takashi Akasaka (Wakayama Medical University)H-Index: 62
view all 14 authors...
Objective The current guideline recommends lowering low-density lipoprotein cholesterol (LDL-C) for the primary management of dyslipidemia in patients at high-risk of cardiovascular events. Patients who have achieved LDL-C levels below the recommended targets may still experience cardiovascular events, suggesting additional therapeutic targets beyond LDL-C. The aim of this study was to investigate whether high-density lipoprotein cholesterol (HDL-C) levels had an impact on plaque stabilization i...
Source
#1Alexandre M.O. Cukier (NIH: National Institutes of Health)H-Index: 2
#2Patrice ThérondH-Index: 22
Last. Anatol Kontush (NIH: National Institutes of Health)H-Index: 53
view all 7 authors...
Aims: High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterized. Methods: Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 ...
4 CitationsSource
#1Erna Sulistyowati (Islamic University)
#2Nur PermatasariH-Index: 2
Last. M. Aris WidodoH-Index: 5
view all 3 authors...
Abstract Objective The purpose of the present study was to analyze the effects of glucose and shear stress on the morphology and density of endothelial cells, actin filamen, and the expression of VE-cadherin. Methods After confluency of endothelial cells (3–4 days), 22 mM of d -glucose was administered for 7 days. Endothelial cells were exposed to shear stress of 10 dyne/cm 2 for varied durations of 5, 8, 12, and 15 min. Morphology of ECs was observed using an inverted microscope before and afte...
Source
#1Hayley Loftus (VU: Victoria University, Australia)H-Index: 3
#2Katie J. Astell (VU: Victoria University, Australia)H-Index: 4
Last. Xiao Q. Su (VU: Victoria University, Australia)H-Index: 10
view all 4 authors...
Limited studies have shown that Coleus forskohlii extract may aid in weight management. This randomized, double blind placebo-controlled clinical study assessed the effects of supplementation with C. forskohlii extract on key markers of obesity and metabolic parameters in overweight and obese individuals. Thirty participants completed the trial and they were randomly assigned to receive either 250 mg of C. forskohlii extract (n = 15) or a placebo twice daily for 12 weeks. All participants were a...
18 CitationsSource
#1Amirhosein KhoshiH-Index: 2
#2Yousef Mortazavi (Zanjan University of Medical Sciences)H-Index: 13
Last. Saeideh Mazloomzadeh (Zanjan University of Medical Sciences)H-Index: 9
view all 7 authors...
Elevated LDL/HDL ratio is an important risk factor for predicting atherosclerosis. Paraoxonase-1 protects LDLs from oxidative modifications and has a protective effect against atherosclerosis. Two common polymorphisms, Q192R and L55M, in PON1 gene can affect PON1 levels and function. The aim of this study was to evaluate the frequency PON1 polymorphisms in individuals with high and normal LDL/HDL ratios. To evaluate Q192R and L55M polymorphisms in Iranian case group (n = 70) with high LDL/HDL ra...
1 CitationsSource
#1Amirhosein KhoshiH-Index: 2
Elevated LDL/HDL ratio is an important risk factor for predicting atherosclerosis. Paraoxonase-1 pro- tects LDLs from oxidative modifications and has a pro- tective effect against atherosclerosis. Two common polymorphisms, Q192R and L55M, in PON1 gene can affect PON1 levels and function. The aim of this study was to evaluate the frequency PON1 polymorphisms in indi- viduals with high and normal LDL/HDL ratios. To evaluate Q192R and L55M polymorphisms in Iranian case group (n = 70) with high LDL/...
#2Sibasis SahooH-Index: 4
Last. Meena ParmarH-Index: 4
view all 6 authors...
Background. We aimed to evaluate a relationship between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) with high density lipoprotein (HDL) cholesterol levels in coronary artery disease (CAD) patients. Methods. A total of 354 patients with angiographically confirmed coronary blockages were enrolled in the study. Hematological indices and lipid profiling data of all the patients were collected. Results. We have observed significant association between HDL and PLR (P = 0.008)...
16 CitationsSource
#1Yuichi Ozaki (Wakayama Medical University)H-Index: 17
#2Atsushi Tanaka (Wakayama Medical University)H-Index: 39
Last. Takashi Akasaka (Wakayama Medical University)H-Index: 62
view all 10 authors...
Background: Although low high-density lipoprotein cholesterol (HDL-C) level has been reported as an independent risk factor for coronary artery disease, few studies addressed the direct relationship between the presence of thin-cap fibroatheroma (TCFA) that is considered as vulnerable plaque in pathology and HDL-C level. The aim of this study was to investigate whether lesion vulnerability is related to HDL-C level in patients with acute coronary syndrome (ACS). Methods and Results: A total of 2...
19 CitationsSource