Exposure of hepatocellular carcinoma cells to low-level As2O3 causes an extra toxicity pathway via L1 retrotransposition induction
Abstract
Various mechanisms have been proposed for toxicity and carcinogenesis pattern of arsenic, a naturally occurring metalloid. The extent to which the long interspersed element-1 (LINE-1) retrotransposon, an ubiquitous retroelement with autonomous mobility, can be influenced upon exposure to low-level arsenic remains to be elucidated. The aim of this study was to evaluate the possible effect of low-level As2O3 on L1 retrotransposition alteration in...
Paper Details
Title
Exposure of hepatocellular carcinoma cells to low-level As2O3 causes an extra toxicity pathway via L1 retrotransposition induction
Published Date
Aug 1, 2014
Journal
Volume
229
Issue
1
Pages
111 - 117
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