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Support of a patient-specific therapeutical acoustic stimulation in tinnitus by numerical modeling

Published on Aug 1, 2012 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
· DOI :10.1109/EMBC.2012.6347258
Lars Haab6
Estimated H-index: 6
(Saarland University),
M. Scheerer1
Estimated H-index: 1
(Saarland University)
+ 2 AuthorsDaniel J. Strauss16
Estimated H-index: 16
(Saarland University)
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Abstract
The pathogenesis of tinnitus involves multiple hierarchical levels of auditory processing and appraisal of sensory saliency. Early tinnitus onset is most likely attributed to homeostatic plasticity in the periphery, while the chronification and decompensation are tightly linked to brain areas for the allocation of attentional resources, such as e.g., the thalamocortical feedback loops and the limbic system. Increased spontaneous firing after sensory deafferentation might be sufficient to generate a phantom perception, yet the question why not every peripheral hearing loss automatically elicits a tinnitus sensation is still to be addressed. Utilizing quantitative modeling of multiple hierarchical levels in the auditory pathway, we demonstrate the effects of lateral inhibition on increased spontaneous firing and the resulting elevation of firing regularity and synchronization of neural activity. The presented therapeutical approach is based on the idea of disrupting the heightened regularity of the neural population response in the tinnitus frequency range. This neural activity regularity depends on lateral dispersion of common noise and thus is susceptible for edge effects and might be influenced by a change in neural activity in bordering frequency ranges by fitted acoustical stimulation. We propose the use of patient specifically adapted tailor-made notched acoustic stimulation, utilizing modeling results for the optimal adjustment of the stimulation frequencies to archive a therapeutical edge-effect.
  • References (27)
  • Citations (6)
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References27
Newest
Published on Sep 21, 2011in The Journal of Neuroscience6.07
Roland Schaette14
Estimated H-index: 14
(UCL: University College London),
David McAlpine29
Estimated H-index: 29
(UCL: University College London)
Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of an external sound source has remained enigmatic. Traditional theories assume that tinnitus is triggered by cochlear damage, but many tinnitus patients present with a normal audiogram, i.e., with no direct signs of cochlear damage. Here, we report that in human subjects with tinnitus and a normal audiogram, auditory brainstem responses show a significantly reduced amplitude of the wave I potential (gene...
Published on Sep 1, 2011in The Journal of Comparative Neurology3.24
Wilhelmina Mulders21
Estimated H-index: 21
(UWA: University of Western Australia),
Dalian Ding42
Estimated H-index: 42
(UB: University at Buffalo)
+ 1 AuthorsDonald Robertson41
Estimated H-index: 41
(UWA: University of Western Australia)
Acoustic trauma caused by exposure to a very loud sound increases spontaneous activity in central auditory structures such as the inferior colliculus. This hyperactivity has been suggested as a neural substrate for tinnitus, a phantom hearing sensation. In previous studies we have described a tentative link between the frequency region of hearing impairment and the corresponding tonotopic regions in the inferior colliculus showing hyperactivity. In this study we further investigated the relation...
Published on Aug 1, 2011in Journal of Clinical Neuroscience1.59
Jae-Won Jang1
Estimated H-index: 1
(CAU: Chung-Ang University),
Young Chul Youn14
Estimated H-index: 14
(CAU: Chung-Ang University)
+ 5 AuthorsOh-Sang Kwon7
Estimated H-index: 7
(CAU: Chung-Ang University)
Abstract Charles Bonnet syndrome (CBS) is characterized by the occurrence of complex visual hallucinations in visually impaired patients who understand that what they see is unreal. The pathophysiologic mechanism of CBS is poorly understood. However, hypermetabolism of the thalamocortical pathway as a result of deafferentation was recently proposed as a possible mechanism. A 69-year-old patient with CBS presented with a 5-year history of visual hallucinations after bilateral visual impairment, w...
Dirk De Ridder43
Estimated H-index: 43
(University of Antwerp),
Ana Belén Elgoyhen21
Estimated H-index: 21
(UBA: University of Buenos Aires)
+ 1 AuthorsBerthold Langguth49
Estimated H-index: 49
(University of Regensburg)
Phantom perception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated “(self-)awareness” and “salience” brai...
Hidehiko Okamoto18
Estimated H-index: 18
,
Henning Stracke9
Estimated H-index: 9
+ 1 AuthorsChristo Pantev60
Estimated H-index: 60
Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic tinnitus patients to self-chosen, enjoyable music, which was modified (“notched”) to contain no energy in the frequency range surrounding the individual tinnitus frequency. After 12 months of regular listening, the target patient group (n = 8) showed significantly...
Carlos Trenado7
Estimated H-index: 7
(Saarland University),
Lars Haab6
Estimated H-index: 6
(Saarland University),
Daniel J. Strauss16
Estimated H-index: 16
(Saarland University)
Auditory evoked cortical potentials (AECPs) have been consolidated as a diagnostic tool in audiology. Further applications of this technique are in experimental neuropsychology, neuroscience, and psychiatry, e.g., for the attention deficit disorder, schizophrenia, or for studying the tinnitus decompensation. In particular, numerous psychophysiological studies have emphasized their dynamic characteristics in relation to exogenous and endogenous attention. However, the effect of corticothalamic fe...
Published on Nov 1, 2008in European Archives of Oto-rhino-laryngology1.75
Marina Savastano12
Estimated H-index: 12
(UNIPD: University of Padua)
The present study was carried out in order to analyze the clinical characteristics of tinnitus both in normal hearing subjects and in patients with hearing loss. The study considered 520 consecutive tinnitus sufferers. The following parameters were considered: age, sex, subjective disturbance caused by tinnitus, subjective judgment of tinnitus intensity, tinnitus laterality, tinnitus duration, tinnitus measurements, normal hearing or associated hearing loss. Among the patients considered, 223 ha...
Published on Aug 1, 2008in Journal of Computational Neuroscience1.57
Per Danzl9
Estimated H-index: 9
(UC: University of California),
Robert Hansen1
Estimated H-index: 1
(UC: University of California)
+ 1 AuthorsJeff Moehlis26
Estimated H-index: 26
(UC: University of California)
We show that populations of identical uncoupled neurons exhibit partial phase synchronization when stimulated with independent, random unidirectional current spikes with interspike time intervals drawn from a Poisson distribution. We characterize this partial synchronization using the phase distribution of the population, and consider analytical approximations and numerical simulations of phase-reduced models and the corresponding conductance-based models of typical Type I (Hindmarsh–Rose) and T...
Published on Feb 1, 2008in Neural Computation2.26
Christoph Börgers18
Estimated H-index: 18
(Tufts University),
Nancy Kopell76
Estimated H-index: 76
(BU: Boston University)
More coherent excitatory stimuli are known to have a competitive advantage over less coherent ones. We show here that this advantage is amplified greatly when the target includes inhibitory interneurons acting via GABAA-receptor-mediated synapses and the coherent input oscillates at gamma frequency. We hypothesize that therein lies, at least in part, the functional significance of the experimentally observed link between attentional biasing of stimulus competition and gamma frequency rhythmicity...
Published on Dec 5, 2007
Sonja Grün17
Estimated H-index: 17
(Riken-BSI: RIKEN Brain Science Institute),
Moshe Abeles41
Estimated H-index: 41
(BIU: Bar-Ilan University),
Markus Diesmann40
Estimated H-index: 40
(Riken-BSI: RIKEN Brain Science Institute)
The signature of neuronal assemblies is the higher-order correlation structure of the spiking activity of the participating neurons. Due to the rapid progress in recording technology the massively parallel data required to search for such signatures are now becoming available. However, existing statistical analysis tools are severely limited by the combinatorial explosion in the number of spike patterns to be considered. Therefore, population measaures need to be constructed reducing the number ...
Cited By6
Newest
Lars Haab6
Estimated H-index: 6
(Saarland University),
Caroline Lehser (Saarland University)+ 4 AuthorsDaniel J. Strauss16
Estimated H-index: 16
(Saarland University)
Recent work has shown that sharp spectral edges in acoustic stimuli might have advantageous effects in the treatment of tonal tinnitus. In the course of this paper, we evaluate the long-term effects of spectrally notched hearing aids on the subjective tinnitus distress. By merging recent experimental work with a computational tinnitus model, we modified the commercially available behind-the-ear hearing aids so that a frequency band of 0.5 octaves, centered on the patient’s individual tinnitus fr...
Published on Feb 1, 2017in Clinical Otolaryngology2.38
Daniel J. Strauss16
Estimated H-index: 16
(Saarland University),
Farah I. Corona-Strauss10
Estimated H-index: 10
(Saarland University)
+ 2 AuthorsRonny Hannemann4
Estimated H-index: 4
Published on Aug 1, 2016 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
Ana E. Uriarte (Saarland University), Lars Haab6
Estimated H-index: 6
(Saarland University)
+ 1 AuthorsDaniel J. Strauss16
Estimated H-index: 16
(Saarland University)
Recent studies have focused on modeling the response of the early auditory processing stages to sound stimuli. However, the influence of sound on the higher stages like the auditory thalamus are not well identified. To understand how different sound stimuli affect the response of neurons in these higher stages, it is necessary to model the auditory pathway from the auditory nerve (AN) through the different stages up to the cortex. In this article we present a model of one of the paths through wh...
Published on Nov 1, 2013
J. Ruckert1
Estimated H-index: 1
(Saarland University),
Lars Haab6
Estimated H-index: 6
(Saarland University)
+ 1 AuthorsDaniel J. Strauss16
Estimated H-index: 16
(Saarland University)
Early tinnitus onset is most likely attributed to an increased spontaneous activity caused by homeo-static plasticity effects in the peripheral auditory system. In a recent modeling study we demonstrated the effects of lateral inhibition on firing regularity related to an increased spontaneous activity. We found that increased activity causes the interconnected neurons to fire more regularly and synchronized. We hypothesized that a suppression of this orchestrated neural activity could be the ph...
Published on Jul 1, 2013 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
Hirofumi Nagashino7
Estimated H-index: 7
(University of Tokushima),
Yohsuke Kinouchi18
Estimated H-index: 18
(University of Tokushima)
+ 1 AuthorsAbhijit S. Pandya11
Estimated H-index: 11
(FAU: Florida Atlantic University)
Tinnitus is the perception of sound in the ears or in the head where no external source is present. Sound therapy is one of the most effective techniques for tinnitus treatment that have been proposed. In order to investigate mechanisms of tinnitus generation and the clinical effects of sound therapy, we have proposed conceptual and computational models with plasticity using a neural oscillator or a neuronal network model. In the present paper, we propose a neuronal network model with simplified...
Published on Jul 1, 2013 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
Phillip J. Hendrickson5
Estimated H-index: 5
(SC: University of Southern California),
Gene J. Yu5
Estimated H-index: 5
(SC: University of Southern California)
+ 2 AuthorsTheodore W. Berger49
Estimated H-index: 49
(SC: University of Southern California)
In previously published work, we showed the progress we've made towards creating a large-scale, biologically realistic model of the rat hippocampus, starting with the projection from entorhinal cortex (EC) to the dentate gyrus (DG). We created the model to help us study how the common components of neurobiological systems in mammals - large numbers of neurons with intricate, branching morphologies; active, non-linear membrane properties; nonuniform distributions throughout membrane surface of th...
Published on Jan 1, 2013
Hirofumi Nagashino7
Estimated H-index: 7
(University of Tokushima),
Yohsuke Kinouchi18
Estimated H-index: 18
(University of Tokushima)
+ 1 AuthorsAbhijit S. Pandya11
Estimated H-index: 11
(FAU: Florida Atlantic University)