Interactions of thioflavin T with serum albumins: Spectroscopic analyses

The interaction of thioflavin T (ThT) with serum albumins from four different mammalian species i.e. human, bovine, porcine and rabbit, has been investigated by circular dichroism (CD), fluorescence spectroscopy and ITC. The binding constant (K) for HSA was found to be 9.9 × 104 M−1, 4.3 × 104 M−1 for RSA, 1.07 × 104 M−1 for PSA and 0.3 × 104 M−1 for BSA and the number of binding sites (n) were 1.14, 1.06, 0.94 and 0.8, respectively, which is...