Low-Density Lipoprotein Levels are One of the Independent Determinants of Circulating Levels of Advanced Glycation End Products in Nondiabetic Subjects

Nonenzymatic modification of proteins by reducing sugars leads to the formation of advanced glycation end products (AGEs), whose process has been reported to progress under diabetes. Recently, diet has been found to be a major environmental source of proinflammatory AGEs in humans. Further, fats or meat-derived products processed by high heat such as broiling have been shown to contain more AGEs than carbohydrates boiled for longer periods....