TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

Volume: 14, Issue: 3, Pages: 323 - 328
Published: Mar 6, 2014
Abstract
Recent advances in gene editing technology have introduced the potential for application of mutagenesis approaches in nonhuman primates to model human development and disease. Here we report successful TALEN-mediated mutagenesis of an X-linked, Rett syndrome (RTT) gene, methyl-CpG binding protein 2 (MECP2), in both rhesus and cynomolgus monkeys. Microinjection of MECP2-targeting TALEN plasmids into rhesus and cynomolgus zygotes leads to...
Paper Details
Title
TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
Published Date
Mar 6, 2014
Volume
14
Issue
3
Pages
323 - 328
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