Original paper
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
Abstract
Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair. Loss of HR accounts for the genomic instability of EOCs and for their cellular hyper-dependence on alternative poly-ADP ribose polymerase (PARP)-mediated DNA repair mechanisms. Previous studies have implicated the DNA polymerase θ (Polθ also known as POLQ, encoded by POLQ) in a pathway...
Paper Details
Title
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
Published Date
Feb 2, 2015
Journal
Volume
518
Issue
7538
Pages
258 - 262
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Notes
History