Pharmacological actions of HS-6, an oxime, on the neuromuscular junction
Abstract
The effect of HS-6 [1-(2-hydroxyiminomethylpyridinium)-1-(3-carboxamidopyridinium)-dimethyl ether] on neuromuscular (NM) transmission was investigated using chick biventer cervicis (CBC), rat diaphragm (RD) and guinea pig ileum longitudinal muscle strip (GPLS) preparations. In the CBC preparation HS-6 did not cause a contraction, whereas it produced a dose-related contraction of the GPLS preparation. HS-6 produced a hemicholinium-like NM...
Paper Details
Title
Pharmacological actions of HS-6, an oxime, on the neuromuscular junction
Published Date
Jan 1, 1979
Volume
53
Issue
2
Pages
135 - 141
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