The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys

Volume: 18, Issue: 1, Pages: 21 - 28
Published: Jan 1, 1997
Abstract
The serotonin 5-HT3 receptor antagonists ondansetron and SEC-579 were tested over a wide dose range (0.000001–0.5 mg/kg, PO) for cognitive-enhancing effects in aged rhesus monkeys. Animals were tested on the following cognitive and motor tasks: 1) acquisition of a visual object discrimination; 2) reversal of a visual object discrimination; 3) the delayed response task, a spatial working memory task; and 4) a fine motor task. This study found...
Paper Details
Title
The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys
Published Date
Jan 1, 1997
Volume
18
Issue
1
Pages
21 - 28
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