miRNAs link metabolic reprogramming to oncogenesis

Volume: 24, Issue: 7, Pages: 361 - 373
Published: Jul 1, 2013
Abstract
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer cell proliferation and metastasis. Alterations in oncogenes and tumor-suppressor genes are involved in the metabolic switch of cancer cells to aerobic glycolysis, increased glutaminolysis, and...
Paper Details
Title
miRNAs link metabolic reprogramming to oncogenesis
Published Date
Jul 1, 2013
Volume
24
Issue
7
Pages
361 - 373
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