Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations.

Volume: 53, Issue: 3, Pages: 1070 - 1076
Published: Nov 15, 2010
Abstract
Neural network breakdown is a key issue in neurodegenerative disease, but the mechanisms are poorly understood. Here we investigated patterns of brain atrophy produced by defined molecular lesions in the two common forms of genetically mediated frontotemporal lobar degeneration (FTLD). Nine patients with progranulin (GRN) mutations and eleven patients with microtubule-associated protein tau (MAPT) mutations had T1 MR brain imaging. Brain...
Paper Details
Title
Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations.
Published Date
Nov 15, 2010
Journal
Volume
53
Issue
3
Pages
1070 - 1076
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