Pharmacokinetic optimization of benzodiazepine therapy for acute seizures. Focus on delivery routes.

Volume: 36, Issue: 6, Pages: 409 - 424
Published: Jun 1, 1999
Abstract
All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for diazepam (<2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) and lorazepam (up to 72 hours), and is not correlated with the plasma concentration-time profiles of these drugs. Although a relationship between the plasma concentration of diazepam, lorazepam and midazolam and their pharmacodynamic effect has been demonstrated in...
Paper Details
Title
Pharmacokinetic optimization of benzodiazepine therapy for acute seizures. Focus on delivery routes.
Published Date
Jun 1, 1999
Volume
36
Issue
6
Pages
409 - 424
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.