Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?
Abstract
Summary. We report on nine children with Shwachman–Diamond syndrome (SDS), eight of whom had clonal abnormalities of chromosome 7. Seven children had an isochromosome 7 [i(7)(q10)] and one a derivative chromosome 7, all with an apparently identical (centromeric) breakpoint. Children with SDS are predisposed to myelodysplasia (MDS) and acute myeloid leukaemia (AML) often with chromosome 7 abnormalities. Allogeneic transplants have been used to...
Paper Details
Title
Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?
Published Date
Dec 1, 2002
Volume
119
Issue
4
Pages
1062 - 1069
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