The serrated pathway of colorectal carcinogenesis

The serrated neoplastic pathway describes a molecular and morphologic continuum, whereby a subset of architecturally serrated polyps progress to colorectal cancers that show BRAF mutation and widespread gene promoter hypermethylation. A subtype of hyper plastic polyp called sessile serrated adenoma has been firmly placed as the dominant precursor lesion in this pathway, whereas the role of the serrated adenoma in this or an alternate serrated...