Review paper
Herpes simplex virus and HIV-1: deciphering viral synergy
Abstract
Recent proof-of-concept randomised controlled trials have shown a causal relation between herpes simplex virus (HSV) type 2 infection and HIV-1 replication in co-infected individuals. We explore the mechanisms that may operate to enhance reciprocal viral replication. Direct interactions could involve HIV-1-related immune deficiency, disruption of mucosal barrier by HSV infection/reactivation, HSV-induced mucosal cell recruitment, transactivation...
Paper Details
Title
Herpes simplex virus and HIV-1: deciphering viral synergy
Published Date
Aug 1, 2008
Volume
8
Issue
8
Pages
490 - 497
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