Efficient and Allele-Specific Genome Editing of Disease Loci in Human iPSCs
Abstract
Efficient and precise genome editing is crucial for realizing the full research and therapeutic potential of human induced pluripotent stem cells (iPSCs). Engineered nucleases including CRISPR/Cas9 and transcription activator like effector nucleases (TALENs) provide powerful tools for enhancing gene-targeting efficiency. In this study, we investigated the relative efficiencies of CRISPR/Cas9 and TALENs in human iPSC lines for inducing both...
Paper Details
Title
Efficient and Allele-Specific Genome Editing of Disease Loci in Human iPSCs
Published Date
Mar 1, 2015
Journal
Volume
23
Issue
3
Pages
570 - 577
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