Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration
Volume: 111, Issue: 27, Pages: 9846 - 9851
Published: Jun 23, 2014
Abstract
Significance In Urodeles, surgical denervation before limb amputation results in regeneration failure. Here we explored the dependency of the peripheral nervous system on tissue replacement in mammalian appendages by performing a comprehensive clonal analysis of hind limb tissues devoid of nerve supply. Our experiments uncover conserved phenotypes, which mimic clinical observations of patients with nerve damage resulting from spinal cord injury....
Paper Details
Title
Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration
Published Date
Jun 23, 2014
Volume
111
Issue
27
Pages
9846 - 9851
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