Asymmetric substitution patterns in the two DNA strands of bacteria.
Abstract
Analyses of the genomes of three prokaryotes, Escherichia coli, Bacillus subtilis, and Haemophilus influenzae, revealed a new type of genomic compartmentalization of base frequencies. There was a departure from intrastrand equifrequency between A and T or between C and G, showing that the substitution patterns of the two strands of DNA were asymmetric. The positions of the boundaries between these compartments were found to coincide with the...
Paper Details
Title
Asymmetric substitution patterns in the two DNA strands of bacteria.
Published Date
May 1, 1996
Volume
13
Issue
5
Pages
660 - 665
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