CTCF-binding elements mediate control of V(D)J recombination
Abstract
Immunoglobulin heavy chain (IgH) variable region exons are assembled from V(H), D and J(H) gene segments in developing B lymphocytes. Within the 2.7-megabase mouse Igh locus, V(D)J recombination is regulated to ensure specific and diverse antibody repertoires. Here we report in mice a key Igh V(D)J recombination regulatory region, termed intergenic control region 1 (IGCR1), which lies between the V(H) and D clusters. Functionally, IGCR1 uses...
Paper Details
Title
CTCF-binding elements mediate control of V(D)J recombination
Published Date
Sep 1, 2011
Journal
Volume
477
Issue
7365
Pages
424 - 430
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