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Nuclear translocation of IGF-1R via p150 Glued and an importin-β/RanBP2-dependent pathway in cancer cells

Published on Apr 1, 2015in Oncogene6.634
· DOI :10.1038/onc.2014.165
S. Packham1
Estimated H-index: 1
(KI: Karolinska Institutet),
Dudi Warsito5
Estimated H-index: 5
(KI: Karolinska Institutet)
+ 4 AuthorsOlle Larsson49
Estimated H-index: 49
(KI: Karolinska Institutet)
Abstract
Nuclear translocation of IGF-1R via p150 Glued and an importin-β/RanBP2-dependent pathway in cancer cells
  • References (52)
  • Citations (17)
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References52
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#1J. Carlijn van Gaal (Radboud University Nijmegen)H-Index: 2
#2Melissa H.S. Roeffen (Radboud University Nijmegen)H-Index: 7
Last. Winette T. A. van der Graaf (Radboud University Nijmegen)H-Index: 51
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Background: Rhabdomyosarcoma (RMS) is an aggressive soft tissue tumour mainly affecting children and adolescents. Since survival of high-risk patients remains poor, new treatment options are awaited. The aim of this study is to investigate anaplastic lymphoma kinase (ALK) and insulin-like growth factor-1 receptor (IGF-1R) as potential therapeutic targets in RMS. Patients and methods: One-hundred-and-twelve primary tumours (embryonal RMS (eRMS) 86; alveolar RMS (aRMS)26) were collected. Expressio...
21 CitationsSource
#1Renato Baserga (Thomas Jefferson University)H-Index: 83
This review examines the effect of targeting the insulin-like growth factor 1 receptor (IGF-IR) in human cancers. The results are disappointing. The causes for the failure are discussed, as well as the possible use of the IGF-IR as a secondary target. J. Cell. Physiol. 228: 675–679, 2013. © 2012 Wiley Periodicals, Inc.
44 CitationsSource
#1Yafang Zhou (CSU: Central South University)H-Index: 9
#2Shu-Sheng Liao (CSU: Central South University)H-Index: 3
Last. Lu Shen (CSU: Central South University)H-Index: 22
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Post-translational modification by SUMO was proposed to modulate the pathogenesis of several neurodegenerative diseases. Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease caused by polyQ-expanded ataxin-3. We have previously shown that ataxin-3 was a new target of SUMOylation in vitro and in vivo. Here we identified that the major SUMO-1 binding site was located on lysine 166. SUMOylation did not influence the subcellular localizat...
21 CitationsSource
#1Cristian IbarraH-Index: 12
Last. Sergio LavanderoH-Index: 51
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Rationale: The ability of a cell to independently regulate nuclear and cytosolic Ca 2+ signaling is currently attributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms in the nucleoplasmic versus the endoplasmic reticulum. In cardiac myocytes, T-tubules confer the necessary compartmentation of Ca 2+ signals, which allows sarcomere contraction in response to plasma membrane depolarization, but whether there is a similar structure tunneling extracellular...
58 CitationsSource
#1Cristian Ibarra (KI: Karolinska Institutet)H-Index: 12
#2Jose Miguel Vicencio (UCL: University College London)H-Index: 28
Last. Sergio Lavandero (University of Chile)H-Index: 51
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Rationale: The ability of a cell to independently regulate nuclear and cytosolic Ca 2+ signalling is currently attributed to the differential distribution of IP3R channel isoforms in the nucleoplasmic versus the endoplasmic reticulum. In cardiac myocytes, T-tubules confer the necessary compartmentation of Ca 2+ signals that allows sarcomere contraction in response to plasma membrane depolarization, but whether there is a similar structure tunneling extracellular stimulation to control nuclear Ca...
51 CitationsSource
#1Irène AsmaneH-Index: 6
#2Emmanuel WatkinH-Index: 4
Last. Jean-Yves BlayH-Index: 78
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#1Ting-Yu Yeh (Johns Hopkins University)H-Index: 3
#2Nicholas J. Quintyne (Johns Hopkins University)H-Index: 5
Last. Trina A. Schroer (Johns Hopkins University)H-Index: 49
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Dynactin is an essential part of the cytoplasmic dynein motor that enhances motor processivity and serves as an adaptor that allows dynein to bind cargoes. Much is known about dynactin's interaction with dynein and microtubules, but how it associates with its diverse complement of subcellular binding partners remains mysterious. It has been suggested that cargo specification involves a group of subunits referred to as the “pointed-end complex.” We used chemical cross-linking, RNA interference, a...
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#1Yu Chieh Wu (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
#2Meifang Zhu (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
Last. Danielle M. Robertson (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
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Background Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R). The presence and biological significance of the Hybrid-R in human corneal epithelium has not yet been established. In addition, while nuclear localization of IGF-1R was recently reported in cancer cells and human corneal epithelial cells, the function and profile of nuclear IGF-1R is unknown. In this study, ...
18 CitationsSource
#1Adam S. Bodzin (Thomas Jefferson University)H-Index: 9
#2Zhengyu Wei (Thomas Jefferson University)H-Index: 5
Last. Cataldo Doria (Thomas Jefferson University)H-Index: 21
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Hepatocellular carcinoma (HCC) is the major form of primary liver cancer which accounts for more than half million deaths annually worldwide. While the incidence of HCC is still on the rise, options of treatment are limited and the overall survival rate is poor. The acquisition of cancer drug resistance remains one of the key hurdles to successful treatment. Clearly, a thorough understanding of the underlying mechanisms is needed for new strategies to design novel treatments and/or to improve th...
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#1Dudi Warsito (Karolinska University Hospital)H-Index: 2
#2Sylvia Sjöström (Karolinska University Hospital)H-Index: 1
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#2Teresa Ribeiro-Rodrigues (UC: University of Coimbra)H-Index: 8
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Connexin43 (Cx43) is commonly associated with direct cell–cell communication through gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma, implicating Cx43 in other biological processes, such as transcription, metabolism, autophagy, and ion channel trafficking. How Cx43 participates in these processes remains largely unknown, although its high turnover rate, capacity to bind to myriad proteins, and the discovery of truncated isoforms of Cx43, ascribe to this pro...
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#1Ravid Solomon-Zemler (TAU: Tel Aviv University)H-Index: 1
#2Yair Pozniak (TAU: Tel Aviv University)H-Index: 8
Last. Haim Werner (TAU: Tel Aviv University)H-Index: 50
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Abstract The insulin-like growth factor-1 receptor (IGF1R) mediates the biological actions of both IGF1 and IGF2. In recent years, evidence has accumulated showing that, in addition to its classical cell-surface distribution, IGF1R translocates to cell nucleus via an apparently SUMO-1-dependent mechanism. While the role of IGF1R in nucleus has not yet been settled, available information suggests that the nuclear receptor displays activities usually linked to transcription factors, including DNA ...
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#1Gayatri Jamwal (CSIR: Council of Scientific and Industrial Research)H-Index: 3
#2Gurjinder Singh (CSIR: Council of Scientific and Industrial Research)H-Index: 5
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Abstract IGF1R is a ubiquitous receptor tyrosine kinase that plays critical roles in cell proliferation, growth and survival. Clinical studies have demonstrated upregulation of IGF1R mediated signaling in a number of malignancies including colon, breast, and lung cancers. Overexpression of the IGF1R in these malignancies is associated with a poor prognosis and overall survival. IGF1R specific kinase inhibitors have failed in multiple clinical trials partly because of the complex nature of IGF1R ...
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#1Natalia Papadopoulos (Ludwig Institute for Cancer Research)H-Index: 3
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Translocation of full-length or fragments of receptors to the nucleus has been reported for several tyrosine kinase receptors. In this paper, we show that a fraction of full-length cell surface platelet-derived growth factor (PDGF) receptor β (PDGFRβ) accumulates in the nucleus at the chromatin and the nuclear matrix after ligand stimulation. Nuclear translocation of PDGFRβ was dependent on PDGF-BB–induced receptor dimerization, clathrin-mediated endocytosis, β-importin, and intact Golgi, occurr...
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Internalization of ligand-activated type 1 IGF receptor (IGF-1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear IGF-1R reportedly associates with clinical response to IGF-1R inhibitory drugs, yet its role in the nucleus is poorly characterized. Here we investigated the significance of nuclear IGF-1R in clinical cancers and cell line models. In prostate cancers, IGF-1R was predominantly membrane-localized in benign glands, while malignant epithelium...
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#2Thomas Robin (French Institute of Health and Medical Research)H-Index: 1
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Abstract Many Receptor Tyrosine Kinases translocate from the cell surface to the nucleus in normal and pathological conditions, including cancer. Here we report the nuclear expression of insulin-like growth factor-1 receptor (IGF1R) in primary human lung tumours. Using lung cancer cell lines and lung tumour xenografts, we demonstrate that the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) gefitinib induces the nuclear accumulation of IGF1R in mucinous lung adenocarcinoma b...
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#1Rossella Titone (UTSW: University of Texas Southwestern Medical Center)H-Index: 9
#2Meifang Zhu (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
Last. Danielle M. Robertson (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
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Insulin and insulin-like growth factor-1 (IGF-1) are present in human tears and likely play an important role in mediating ocular surface homeostasis. We previously characterized the IGF-1/insulin hybrid receptor (Hybrid–R) in corneal epithelial cells and found that it was activated by IGF-1 and not insulin; and reported the novel finding that it localized to the corneal epithelial cell nucleus. Since the corneal epithelium is an insulin insensitive tissue and does not require insulin for glucos...
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#1Florencia ClémentH-Index: 1
#2A. MartinH-Index: 11
Last. Patricia PennisiH-Index: 18
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Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas. Samples were taken at the time of the initial surgery; IGF-1R expression and localization were cha...
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#1Jun Yang (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Yan Liu (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Jian Luo (HUST: Huazhong University of Science and Technology)H-Index: 1
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Background Cholangiocarcinoma is one of the deadly disease with poor 5-year survival and poor response to conventional therapies. Previously, we found that p27kip1 nuclear-cytoplasmic translocation confers proliferation potential to cholangiocarcinoma cell line QBC939 and this process is mediated by crm-1. However, no other post-transcriptional regulation was found in this process including sumoylation in cholangiocarcinoma.
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Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer
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