Model selection bias and Freedman’s paradox

In situations where limited knowledge of a system exists and the ratio of data points to variables is small, variable selection methods can often be misleading. Freedman (Am Stat 37:152–155, 1983) demonstrated how common it is to select completely unrelated variables as highly “significant” when the number of data points is similar in magnitude to the number of variables. A new type of model averaging estimator based on model selection with...