Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism.

Volume: 29, Issue: 29, Pages: 102 - 111
Published: Dec 1, 2014
Abstract
Allosteric regulation of enzyme activity plays important metabolic roles. Here we review the allostery of enzymes of amino-acid metabolism conferred by a discrete domain known as the ACT domain. This domain of 60-70 residues has a βαββαβ topology leading to a four-stranded β4β1β3β2 antiparallel sheet with two antiparallel helices on one face. Extensive sequence variation requires a combined sequence/structure/function analysis for identification...
Paper Details
Title
Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism.
Published Date
Dec 1, 2014
Volume
29
Issue
29
Pages
102 - 111
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