Functional Interaction of DNA Topoisomerase IIα With the β-Catenin and T-Cell Factor-4 Complex

Background & Aims: The Wnt signaling pathway is activated constitutively in the majority of colorectal cancers as a result of mutation in either the adenomatous polyposis coli or the CTNNB1 gene, and blockage of the pathway has been considered feasible as molecular therapy against colorectal cancer. DNA topoisomerase IIα (Topo IIα) is a component of the β-catenin/T-cell factor-4 (TCF-4) nuclear complex. We examined the functional significance of...