Review paper

Checkpoint kinase inhibitors: a review of the patent literature

Volume: 19, Issue: 2, Pages: 165 - 197
Published: Feb 1, 2009
Abstract
Background: The checkpoint kinases, Chk1 and Chk2 are Ser/Thr protein kinases, which function as key regulatory kinases in cellular DNA damage response pathways limiting cell-cycle progression in the presence of DNA damage. The development of checkpoint kinase inhibitors for the treatment of cancer has been a major objective in drug discovery over the past decade, as evidenced by three checkpoint kinase inhibitors entering clinic trials since...
Paper Details
Title
Checkpoint kinase inhibitors: a review of the patent literature
Published Date
Feb 1, 2009
Volume
19
Issue
2
Pages
165 - 197
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