Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats

Aims To investigate whether metformin regulates chemerin expression in vivo by alleviating ER stress. Methods Male Sprague-Dawley rats were fed a high-fat or normal diet for 10 weeks to induce insulin resistance. During the following 6 weeks, the rats were divided into four groups: normal diet without treatment (NC), normal diet with metformin treatment (NM), high-fat diet without metformin (HF), and high-fat diet with metformin (HM). Body...