Review paper
Current strategies for diversity-oriented synthesis
Abstract
Compounds accessed through diversity-oriented synthesis (DOS) are showing promise in modulating the activities of several targets that are currently considered ‘undruggable’. Recently many new DOS pathways have been developed employing multi-component reactions, cycloadditions, ring-closing metathesis and tandem processes. Functional group pairing and ‘build/couple/pair’ strategies have been described as a means for generating structural...
Paper Details
Title
Current strategies for diversity-oriented synthesis
Published Date
Jun 1, 2010
Volume
14
Issue
3
Pages
362 - 370
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